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Volume 7, Issue 1 (Suppl) J Clin Exp Pathol
ISSN: 2161-0681 JCEP, an open access journal
Pediatric Pathology & Laboratory Medicine 2017
March 15-16, 2017
Page 48
Notes:
conferenceseries.com
March 15-16, 2017 London, UK
12th International Conference on
Pediatric Pathology & Laboratory Medicine
The immunoexpression of glucocorticoid receptors in breast carcinomas, lactational change and
normal breast epithelium and its possible role in mammary carcinogenesis
Glucocorticoids (GC) are known to play a role in mammary development and differentiation, thus it is of interest to attempt
to delineate it’s immunoexpression across a spectrum of mammary epithelia. This study aims to delineate the distribution
pattern of GRs in malignant versus non-malignant epithelium with particular emphasis on lactational change epithelium as
its cells are considered the most terminally differentiated mammary cells. Immunohistochemistry (IHC) for glucocorticoid
receptors (GR) was performed on archival formalin fixed paraffin embedded tissue blocks of 97 cases comprising 53 invasive
carcinomas, 21 cases with lactational change and 23 cases showing normal mammary tissue histology. The results reveal an
over-expression of GR receptors in mammary malignant epithelium compared to both the normal and lactational group
individually and combined together as a non-malignant group. This is the first study to compare GR expression in human
lactating epithelium versus malignant and benign epithelium. GR overexpression was also established in HER-2 negative
cancers as compared to HER-2 positive ones, while GR immunoexpression in tumors categorized according to grade, estrogen
(ER), progesterone receptor (PR) or axillary lymph node (ALN) status showed no statistical difference. It seems that GR
expression in mammary epithelium promotes the development of HER-2 negative breast cancer, thus such receptors may
become targets for the development of therapeutic interventions. Further studies are required to determine the level of caution
that is needed if any in the use of steroid therapy in such category of patients.
Biography
Raja Alyusuf is a Fellow of Royal College of Pathologists since 1998. She is a Consultant Histopathologist with special interest in the area of Breast Treatment. She
chaired the Department of Pathology at Salmaniya Medical Complex for 10 years after which she became the Deputy Chief of Medical Staff for Diagnostic Affairs
at the Salmaniya Medical Complex. In addition, she is a part-time Associate Professor of Pathology at the Royal College of Surgeons, Ireland-Bahrain branch. She
has over 20 publications is reputable journals and is a member of a number of international and national professional associations.
Raja Alyusuf
Salmaniya Medical Complex, Ministry of Health, Bahrain
Raja Alyusuf, J Clin Exp Pathol 2017, 7:1 (Suppl)