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Volume 8 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X
Page 22
Notes:
October 22-23, 2018 Berlin, Germany
&
JOINT EVENT
3rd International Conference on
Digestive and Metabolic Diseases
Pediatric Gastroenterology Hepatology & Nutrition
Pediatric Gastro 2018
Digestive Diseases 2018
October 22-23, 2018
13th International Conference on
The effectiveness of oral antiviral (Sofosbuvir/ledipasvir) in treating children with HCV infection
Objectives: to determine the efficacy of (Sofosbuvir/ledipasvir) in treating children with HCV infection.
Patients and methods: Patients with positive HCV PCR, aged 7 to 18 years were enrolled. History and clinical examinations
and investigations were conducted. HCV genotyping was done (if affordable). Sofosbuvir was given to all patients once daily.
Ribavirin was added for INF-experienced patients or with established cirrhosis. Follow up with liver function and renal function
and PCR was done at 12 weeks (end of treatment); then after 12 weeks post treatment (SVR12). Total duration of therapy was
12 weeks. Extended to 24 in cases with established cirrhosis. Computer program SPSS version 20 was used for data analysis.
Results: the number of patients were 22, with mean age of 12.5 years, 14 boys (63.6%), and 8 girls (36.4%). Genotype 1 was the
dominant type (75%). SVR 12 was achieved in 20 patients (90.9%), the remaining 2 (9.1%) had partial virological response.
HBV co-infection was found in 5 cases; they were kept on Entecavir during the course of treatment. All achieved SVR12
for HCV and decrease titter for HBV. Even INF-experienced patients (7 patients 31.8%) were responsive with SVR12. The
treatment was well tolerated.
Conclusion: Sofosbuvir/ledipasvir is effective in treating HCV in children, and is well tolerated.
Key word: Direct acting antivirals, hepatitis C virus, Sofosbuvir/ledipasvir, Pediatrics, children.
Biography
Ban is a senior lecturer atAl mustansiriyah Medical college, specialist pediatrician working in the field of Pediatric Gastroenterology and hepatology for more than 8 years at
the GIT and Hepatology Center and in the GIT Clinic at Central Child Teaching Hospital in Baghdad /Iraq. She had completed MRCPCH 2014, achieved 1st rank graduate
of the Iraqi board of Pediatrics. She is a member of the BSPGAN.
Ban Adil Al-Kaaby
Zagazig University, Egypt
Ban Adil Al-Kaaby, J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C7-082