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Volume 8

Journal of Clinical & Experimental Pathology

Pathology Summit 2018

July 02-03, 2018

Page 13

conference

series

.com

July 02-03, 2018 Bangkok, Thailand

15

th

Global Experts Meeting on

Pathology and Laboratory Medicine

Regulatory peptides: The mechanisms of effects on the pain-induced aggressive-defensive behavior

F

or many years we have studied the regulatory peptides effects on the integration of nervous, endocrine and immune

mechanisms in the pain-induced aggressive-defensive behavior in rat. 23 analogues of the natural hypothalamic-pituitary

peptides and other peptides synthesized in the Russian Academy of Sciences and “Serva” were administered in intra-peritoneal

and brain intra-ventricular injections. With the use of the modified foot-shock model the following regularities of peptide

effects were revealed. (1) The key role in peptide effects is played by the L-arginine or L-lysine amino acids residues. In

particular, only the administration of arginine containing peptides increased pain sensitivity and aggression, (2) binding of the

tripeptide Pro-Gly -Pro to the amino acid (Arg) or oligopeptide (ACTH 4-7) essentially modifies the influence on the affective

aggression, (3) the intensity of aggression depends on the excitability of the brain emotional negative systemmore than on pain

perception. This was demonstrated due to effects of encephalin analogues, (4) peptide effects seemed to be dependent on the

brain locus of their primary application and (5) neuropeptide effects were more expressed in rats with the higher excitability

of nociceptive, emotional, opioid and M-cholinergic systems. Since analogues of the natural peptides have been used, there is

a reason to believe that obtained data make it possible to elucidate the mechanisms of the development of the pain-induced

affective aggression and to develop means for its correction.

Biography

Severyanova L A has performed research at Kursk State Medical University and received her PhD and later Russian “Doctor of Medicine” at the Pavlov Institute

of Physiology of the Russian Academy of Sciences. She has been the Head of the Department of Pathophysiology, Dean of the International Faculty, Professor of

Pathophysiology and Honored Worker of Higher School. Her scientific interest is the integration of nervous, endocrine and immune mechanisms in the systemic

reactions of the body. She has published more than 50 articles in reputed journals and three monographs.

severlud@yandex.ru

Severyanova L A

Kursk State Medical University, Russia

Severyanova L A, J Clin Exp Pathol 2018, Volume 8

DOI: 10.4172/2161-0681-C2-047