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Volume 6 Issue 6(Suppl)

J Alzheimers Dis Parkinsonism

ISSN: 2161-0460 JADP, an open access journal

Page 21

Parkinsons 2016

December 05-07, 2016

conference

series

.com

December 05-07, 2016 Phoenix, USA

2

nd

International Conference on

Parkinson’s Disease & Movement Disorders

Degeneration of the Thalamostriatal System: APotential Source of Early Cognitive Impairments in Parkinson’s

Disease

T

he existence of the thalamostriatal projection has long been known, but, until recently, the functional role of this system

in normal and diseased conditions remained poorly understood. The main source of the thalamostriatal system is the

centromedian/parafascicular (CM/Pf) caudal intralaminar nuclear complex, although other non-CM/Pf nuclei also contribute

to this neural system. In addition to their thalamic origin, these thalamostriatal systems differ in their pattern of striatal

innervation, synaptic properties, physiologic effects upon striatal neurons activity, glutamate receptors expression and

extent of degeneration in Parkinson’s disease and other neurodegenerative disorders. Despite direct monosynaptic excitatory

connections with striatal projection neurons and interneurons, the effects of CM/Pf activation upon striatal neurons activity

in vivo are complex, and likely involve intrastriatal GABAergic networks. Behaviorally, the CM/Pf-striatal system regulates

attention-related cognitive processes through regulation of striatal cholinergic interneuron responses to salient stimuli. It has

been suggested that the CM/Pf-striatal system plays a key role in behavioral switching and response biases for reward-oriented

actions and learning. Because the CM/Pf complex heavily degenerates in Parkinson’s disease, this thalamic pathology may

contribute to attention-related cognitive deficits frequently seen in PD patients. The CM/Pf complex is also considered as a

promising neurosurgical target for Tourette’s syndrome, and possibly Parkinson’s disease.

Biography

Yoland Smith got his PhD in Neuroscience from Laval University (Quebec, Canada) in 1988. After postdoctoral trainings in Oxford and Johns Hopkins University,

he became Assistant professor in the Department of Anatomy at Laval University. Since 1996, he holds a faculty position at the Yerkes Primate Center of Emory

University (Atlanta, GA). He has published over 250 manuscripts on the anatomy of the basal ganglia and the pathophysiology of Parkinson’s disease. He is editor

of prestigious journals in the field of Neuroscience, serve on NIH study sections and sit on the Advisory board of the Dystonia Medical Research Foundation. He

is deeply involved in graduate education as principal investigator of various NIH training grants and previous director of the graduate neuroscience program at

Emory University.

ysmit01@emory.edu

Yoland Smith

Emory University, USA

Yoland Smith, J Alzheimers Dis Parkinsonism 2016, 6:6(Suppl)

http://dx.doi.org/10.4172/2161-0460.C1.023