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Volume 9
Journal of Clinical & Experimental Ophthalmology
Ophthalmology Conference 2018
September 17-18, 2018
September 17-18, 2018 Tokyo, Japan
17
th
Asia Pacific Ophthalmologists Annual Meeting
Athar Shadmani et al., J Clin Exp Ophthalmol 2018, Volume 9
DOI: 10.4172/2155-9570-C6-094
Comparison of effects of activated omental cell with fat derived stem cell on rat limbal corneal
alkaline injury
Athar Shadmani, Masoomeh Eghtedari and Mahboobeh Razmkhah
Shiraz University of Medical Sciences, Iran
Purpose:
To investigate whether autologous activated omental cells are as effective as fat derived stem cells, in healing process
of alkaline burn in limbus of rats.
Methods:
Corneal alkaline burn was created in three groups of rats (each group was composed of six rats).Then each group were
treated differently: Group 1 (control group), with topical medication only, group 2: sub-conjunctivally injected by Autologous
Activated Omental Cell (AAOC) after alkaline burn induction , group 3: sub-conjunctivally injected by non-autologous
abdominal Fat Derived Stem Cells (FDSC).Clinical outcome was evaluated after 2 months by corneal epithelialization, corneal
opacity and neovascularization. Pathologic study was done to access corneal integrity and cell proliferation.
Results:
After three weeks all three groups had relatively same degree of corneal neovascularization and opacity. But at the
time of 2-month follow-up, group 3 rats showed the best clinical results with a more clear healed cornea compared with other
groups. All rats on group 1 developed severe central corneal neovascularization and opacity with no healing. Auto evisceration
was done in two of them. In group 2: Most cases achieved a clear cornea with peripheral neovascularization two of them
developed central corneal neovascularization, but in group 3, none of rats developed central corneal neovascularization and all
corneas were relatively clear with no epithelial defects.
Conclusion:
Activated omental cells are as effective as fat derived stem cells in prevention of corneal neovascularization and wound
healing after alkaline burn. Some differences between group 2 and 3 were detected, that should be evaluate in future studies
Biography
Athar Shadmani is working in Shiraz University of Medical Sciences, Iran
drshadmani@gmail.com