obesity-middle-east-2018-posters

3 / 7

Page 46
conferenceseries.com
Volume 8 Journal of Obesity & Weight Loss Therapy Obesity Middle East 2018
June 25-26, 2018
June 25-26, 2018 Dubai, UAE
Middle East Obesity, Bariatric Surgery
and Endocrinology Congress
Christos Tsagkaris et al., J Obes Weight Loss Ther 2018, Volume 8
DOI: 10.4172/2165-7904-C3-064
Serotonin and leptin: Hormonal processes in the brain as regulators of body weight
Christos Tsagkaris1, A Karkala2, E Petropoulou3, D Scordilis4, E Sartzetakis5, P Sartzetaki5, A Antoniou5, N Sevdalis4, S Kara Ali 3, T Angelopoulos1, A
Moustaka1, R Datseri6, N Papakonstantinou6, A Logotheti6, A Vakka 7 and D Desse1
1University of Crete, Greece
2Aristotle University of Thessaloniki, Greece
3Technical University of Athens, Greece
4Medical University of Sofia, Bulgaria
5Carol Davila University of Medicine and Pharmacy, Romania
6Commenius University in Bratislava, Slovakia
7University of Patras, Greece
In recent years, the study of pathophysiology has made great progress by investigating pleiotropic hormonal interactions and their
coexistence with behavioral factors. Leptin, which is produced in adipose tissue and orchestrates a hypothalamic feedback system,
has become widely known as the appetite hormone. At the same time, serotonin transferability is correlated with cholesterol levels. The
purpose of this study is to investigate the contribution of the brain to weight control. We focus on leptin and serotonin. The materials
and methods utilized during this study include a review of publications in a reputable electronic database (PubMed, Elsevier), using
specific keywords in the search engine (microglia, obesity, POMC, brain, serotonin, cholesterol). We selected articles from reliable
journals whose results were summed up and compared. The results show that in animal models with leptin receptor insufficiency
in myeloid cells, hyperphagia and weight gain occur. In the hypothalamus, the number of POMC neurons and α-MSH projections
from the arcuate nucleus in the sub-ventricular nucleus are reduced, in combination with the presence of significantly less microglia
with phagocytic capacity. At the same time, in a sample of volunteers, cholesterol levels appeared to correlate with the expression of
serotonin transporters at the gene level. Correlation is particularly strong in younger people. To conclude, hormonal processes appear
to affect human psychology by exerting double biochemical and behavioral control over body weight. This interpretation makes it
seemingly more difficult to understand the mechanisms of obesity. However, its individual data provides opportunities for developing
new biomarkers and therapeutic approaches.
Biography
Christos Tsagkaris is an undergraduate Medical student in the University of Crete, Faculty of Medicine. He is a Fellow of the Gastrointestinal Immunology Laboratory
and the Museum of Medicine of the University of Crete. Moreover he has a special interest in humanities, taking part in medical history and sociology projects.