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Volume 7, Issue 7 (Suppl) J Obes Weight Loss Ther, an open access journal
ISSN:2165-7904 Obesity & Fitness Expo 2017
November 13-15, 2017
November 13-15, 2017 | Atlanta, USA 17th World Fitness Expo
16th International Conference and Exhibition on
Obesity & Weight Management
&
Obesity leads to iron retention in the duodenum of mice likely due to increased production of adipose-derived
hepcidin
Shougang Wei, Wanshan Zhang, Chen Wang and Yanqiang Cao
Capital Medical University, China
Obese people and animals have higher rates of iron deficiency (ID) than their normal weight peers. It was still uncertain whether
obesity-related ID is a true or functional deficiency of iron. This study was to determine the effects and the possible underlying
mechanisms of obesity on duodenal iron absorption and liver iron accumulation. C57BL/6J mice were randomly divided into high-fat
diet-induced obese (DIO) group and normal control (NC) group to be fed respectively for 16 weeks. Oral iron absorption was tested
by measuring serum iron, liver iron and the retained duodenal iron 90 min after intragastric administration of 57 FeSO4 solution. The
protein expression levels of iron transporters in duodenum and liver were evaluated by Western blotting. Hepcidin mRNA levels in
the liver and adipose tissues were quantified by real-time RT-PCR. The results showed that DIO mice had significantly higher iron
retention in the duodenum, lower iron concentration in plasma and liver than NCmice. The protein expression levels of ferroportin-1
(Fpn1) in duodenum and transferrin receptor-2 (TfR2) in the liver were markedly decreased in DIO mice. Hepcidin mRNA levels in
visceral adipose tissue but not in the liver were higher in DIO mice than NC mice. In conclusion, obesity-related ID may attributed to
impaired intestinal iron absorption of which iron being retained in the duodenal enterocytes, not to that iron being accumulated in
the liver. Increased expression of visceral adipose hepcidin probably is the immediate cause for the malabsorption of iron in obesity
by inducing reduction of the duodenal Fpn1.
Biography
Shougang Wei serves as professor, Ph.D. supervisor and deputy director at the Department of Children’s and Women’s Health, School of Public Health, Capital Medical
University, Peking, China. Mr. Wei has been engaged in the study of child and adolescent health, mainly focused on the field of childhood obesity about its health risks,
pathogenic factors and preventive and treatment measures.
Shougang Wei et al., J Obes Weight Loss Ther 2017, 7:7 (Suppl)
DOI: 10.4172/2165-7904-C1-54