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Volume 7, Issue 6 (Suppl)
J Nutr Food Sci
ISSN: 2155-9600 JNFS, an open access journal
Nutritionists 2017
October 02-03, 2017
October 02-03, 2017 Kuala Lumpur, Malaysia
17
th
Global Dieticians and
Nutritionists Annual Meeting
Brain coordination and the association with diet in prediabetes
Yi-Cheng Hou
1
, Jiun-Rong Chen
1
, Shwu-Huey Yang
1
, Yu-Te Wu
2
, Cheng-yu Chen
3
and Chien-Han Lai
2
1
Taipei Medical University, Taiwan
2
National Yang-Ming University, Taiwan
3
Taipei Tzu Chi Hospital, Taiwan
T
he functional connectivity of diabetes can help us explain the brain function decline in hyperglycemic status. However, the
issue has not been addressed much in prediabetes. Therefore, we designed this study to investigate the inter-hemispheric
coordination in the prediabetes. 64 prediabetic patients and 54 controls were enrolled in this protocol. They received the
structural and resting-state functional magnetic resonance imaging screen. The imaging data were preprocessed and analyzed
to obtain voxel-mirrored homotopic connectivity (VMHC), which can measure inter-hemispheric coordination. The VMHC
values were compared between two groups with age and gender as covariates. The controls had higher VMHC values than
prediabetic patients in bilateral anterior cingulate cortex. The prediabetic patients had higher VMHC values than controls
in bilateral middle frontal gyrus. The VMHC values were also negatively correlated with pre-prandial serum glucose level in
inferior frontal gyrus of prediabetic patients. In addition, the VMHC values of prediabetic patients were negatively correlated
with total carbohydrate and calorie intake in anterior cingulate cortex. The inter-hemispheric coordination in anterior sub-
network of default mode network and fronto-cingulate regions would play a role in the pathophysiology of prediabetes. The
diet impact on the inter-hemispheric coordination is also an interesting issue.
anny321@tmu.edu.comJ Nutr Food Sci 2017, 7:6 (Suppl)
DOI: 10.4172/2155-9600-C1-051