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Volume 4 Clinical Neuropsychology: Open Access Neuropsychiatry 2018
August 27-28, 2018
August 27-28, 2018 Tokyo, Japan
8th Global Experts Meeting on
Advances in Neurology and Neuropsychiatry
Philip Anthony McMillan, ClinNeuropsychol 2018, Volume 3
DOI: 10.4172/2472-095X-C1-002
Integrated biochemical theory of delirium and experience with pharmacological reversal
Philip Anthony McMillan
Hull and East Yorkshire Hospitals NHS Trust, UK.
Delirium is a significant problem in older hospital admissions, with worse clinical outcomes, prolonged hospital stay and
functional disability. This presentation will cover the clinical experience of managing these complex patients during their
hospital stay. The basis of this theory is with hepatic encephalopathy and the fact that all forms of delirium are clinically
consistent. Looking to explain the integrated theory of delirium based on brain glutamate and ammonia management. This will
demonstrate the biochemical aspects of delirium and how it is related to other conditions and most significantly how there is a
higher incidence of delirium in dementia. Anecdotal experience of reversing delirium using this biochemical framework and
use of simple medication in hospital has been very successful with up to 70% of patients demonstrating clinical improvement.
This theory has the potential to revolutionize our care of older patients and give insight into the links between delirium and
dementia.
Biography
Philip Anthony McMillan is a Consultant in the NHS as a Medical Expert. His primary focus has been around geriatrics and neurological rehabilitation and has
developed unique perspectives on the capacity of the brain to recover from injuries and disease. Through international collaboration he has proposed a nutritional
protocol for dementia reversal and has recently had a breakthrough theory on the pathology of dementia. His current aim is to lead the field of dementia to a new
direction of research and treatment of this devastating disease.