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.com
Volume 4
Clinical Neuropsychology: Open Access
Neuropsychiatry 2018
August 27-28, 2018
August 27-28, 2018 Tokyo, Japan
8
th
Global Experts Meeting on
Advances in Neurology and Neuropsychiatry
Combined effect of Baclofen andAcamprosate in experimental models of peripheral neuropathic pain
in Wistar rats
Varun Vikas Vij
Baba Farid University of Health Sciences, India
Background&Aim:
Neuropathic Pain (NP) is defined as pain associated with damage or permanent alteration of the peripheral
or central nervous system. Current drug treatment for the management of neuropathic pain associated with various adverse
effects. The present study was designed to investigate the combined effect of Acamprosate and Baclofen in experimental model
of peripheral neuropathic pain in Wistar rats.
Material &Methods:
Neuropathic pain was induced by Chronic Constriction Injury (CCI) of sciatic nerve in rats. Acamprosate
(100 and 200 mg/kg p.o) and Baclofen (10 and 20 mg/kg p.o) was given in different groups for 14 days starting on 7
th
day post
sciatic nerve ligation. Further combination of Acamprosate (100 mg/kg p.o) and Baclofen (10 mg/kg p.o) was also given to one
group. On 1
st
, 3
rd
, 7
th
, 14
th
and 21
st
day behavioral parameters like mechanical allodynia and thermal hyperalgesia were assessed.
Then animals were sacrificed on 22
nd
day and biochemical parameters (GSH, LPO, Catalase, Nitrite and SOD) were assessed.
Results:
Ligation of sciatic nerve significantly induced mechanical allodynia and thermal hyperalgesia with increase in
oxidative stress (increase in LPO and Nitrite) and decline of anti-oxidant enzyme levels (Catalase, SOD and GSH) in sciatic
nerve homogenate. Acamprosate (100 and 200 mg/kg p.o) and Baclofen (10 and 20 mg/kg p.o) attenuated all the behavioral
and biochemical parameters alone and/or combination.
varunkumar1982dec@gmail.comClinNeuropsychol 2018, Volume 3
DOI: 10.4172/2472-095X-C1-003