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Volume 4
Clinical Neuropsychology: Open Access
Neuropsychiatry 2018
August 27-28, 2018
Page 15
Notes:
conference
series
.com
August 27-28, 2018 Tokyo, Japan
8
th
Global Experts Meeting on
Advances in Neurology and Neuropsychiatry
Dementia is a disease of the ependymal layer: Novel theory from looking at cognitive impairment in multiple
sclerosis
T
he intricacies of dementia are explored in relation to varied studies on brain atrophy in multiple sclerosis and used to
delineate the primary pathology of the latter. The theory examines the high frequency of cognitive impairment in multiple
sclerosis and its early manifestation during the disease. The fact that there is associated brain atrophy cannot be explained by
the degree of damage to neurons. Carlos in 2015 noted a 5 to 10 times greater rate of atrophy in multiple sclerosis. The cognitive
changes with multiple sclerosis are then correlated embryologically to the subependymal zone explaining the pathology of brain
atrophy and why we have not made more progress through research. Our understanding of the blood CSF barrier and the brain
CSF interaction is poorly understood and probably holds the key to the symptoms of dementia. This interaction between the
CSF and brain interstitial space is coordinated by the ependymal and subependymal zone of the brain. This is a novel concept
will aim to explain the links of all forms of dementia, as well as directing fertile areas for research.
Biography
Philip Anthony McMillan is a Consultant in the NHS with over 23 years of medical expertise. His primary focus has been around geriatrics and neurological
rehabilitation and has developed unique perspectives on the capacity of the brain to recover from injuries and disease. Through international collaboration he has
proposed a nutritional protocol for dementia reversal and has recently had a breakthrough theory on the pathology of dementia. His current aim is to lead the field
of dementia to a new direction of research and treatment of this devastating disease.
philip.mcmillan@nhs.netPhilip Anthony McMillan
Hull and East Yorkshire Hospitals NHS Trust, UK
Philip Anthony McMillan, ClinNeuropsychol 2018, Volume 3
DOI: 10.4172/2472-095X-C1-001