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conferenceseries
.com
Volume 3
October 03-04, 2018 Osaka, Japan
Pediatric Neurology & Medicine
3
rd
International conference on
N
euroscience
, N
euroradiology
and
I
maging
Neuroimaging 2018
October 03-04, 2018
J Pediatr Neurol Med 2018, Volume 3
DOI: 10.4172/2472-100X-C1-003
Differences between cumulative effects of first and second generation antipsychotics on the cortical
thickness: Mega-analysis of 214 patients with schizophrenia from São Paulo, Brazil
Carlos T Cerqueira
1
, Pedro G Rosa
1
, André Zugman
2
, Andréa Jacowiski
2
, Rodrigo Afonseca Bressan
2
and Geraldo Busatto Filho
1
1
University of São Paulo, Brazil
2
Federal University of São Paulo, Brazil
S
chizophrenia is a severemental disorder that impact individual social functioninganddefy recent developments and treatment
strategies. One fundamental problem to face schizophrenia is to balance the benefits and side effects of Antipsychotics (AP),
including their effects on the cerebral cortex. Generally, morphometric studies on schizophrenia suffer from limited sample size.
Consequently, they are unable to distinguish many confounding effects of illness-related factors from AP effects. Multi-centric
transversal studies are reliable alternatives to evade these limitations. The present study is a conjunction analysis of two studies
conducted in the State of São Paulo (5 samples) using data from 214 patients with schizophrenia by DSM-IV. Image quality
control and analysis was conducted following ENIGMA consortium standards for surface measures. Brain thickness was taken
as response variable, AP class was taken as fixed factor, life cumulative doses of AP and other variables as explain variables.
Positive correlations with brain thickness were found bilaterally on the insula and left cingulate (p<0.001, corrected), among
other regions. Smaller mean thickness for first generation AP were found on the right pre-central, fusiform supramarginal
girii, left cingulate and insula (p<0.001, corrected). Smaller mean thickness for cumulative doses of first AP relative to the
second generation were found, predominantly, on the lateral surfaces of both hemispheres. These findings were located in
the right precentral, supramarginal, rostral middle frontal, post-central, supramarginal, fusiform and inferior temporal girii,
as well as, in the left lateral occipital, superior temporal, inferior parietal, superior parietal, fusiform, supramarginal, caudal
middle frontal, pars opercularis and precentral gyrii (p<0.001, GLM, corrected by Monte Carlo simulations). Other tested
correlations/covariations did not survive the correction for multiple comparisons. The findings obtained expand previous
results obtained for volumetry and introduce novel findings of protective effects of second generation in the treatment of
schizophrenia compared to first generation AP.
carlostoledocerqueira@gmail.com