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Journal of Community Medicine & Health Education | ISSN: 2161-0711 | Volume 8

Medical Sociology & Public Health

World Congress on

Public health and Epidemic diseases

International Conference on

September 21-22, 2018 | Dallas, USA

Trends of antimicrobial resistance in gram-negative isolates from an ICU over 3 year

Sachin H Jain

Hinduja Healthcare Hospital, India

o study the changing patterns of antimicrobial resistance in gram-negative

Bacilli esp. Escherichia coli, Klebsiella

pneumoniae, Pseudomonas aeruginosa and Acinetobacter

species from a 37 bedded ICU of a private hospital. The antibiotic

susceptibilities were determined by using the Vitek-2 system. A total of 13410 clinical samples were screened over a period of

3 years, among which 16.77 percent (2250 isolates) were culture positive. In recent years there has been an increased incidence

of extended-spectrum β- lactamase (ESBL). The ESBL producing

Escherichia coli

and

Klebsiella pneumonia

has shown an

increase in resistance to the tune of 80-90% in three years. The prevalence of resistant strains of

Acinetobacter

species and

Pseudomonas aerugnosa

has shown an increase in Imipenem and Meropenem resistance at the rate of 75-80%. Antibiotic

resistance has shown an increase in gram-negative pathogens and thereby has created a significant problem in choosing the

right antibiotic for empirical usage. The rise in resistance has left little choice for the clinicians to select antibiotics.

Klebsiella

pneumonia

ESBL and

Escherichia coli

ESBL have become dominant organisms in ICU. Piperacillin + Tazobactam, Imipenem

and Amikacin have decreased sensitivity against Enterobacteriaceae. Old antibiotic compounds such as Polymyxins,

Fosfomycin and Aminoglycosides are re-emerging as valuable alternatives for the treatment of ESBL producing bacteria. Cases

of MDR.

Escherichia coli

and

Klebsiella pneumonia

have increased in recent years as the most frequent cause of hospital-

acquired infections.

Biography

Sachin H Jain has completed his Masters in Microbiology at 25 years from Seth G.S. Medical College and KEM Hospital, Mumbai India. He worked in Sydney,

Australia before moving back to Mumbai and worked as Head Microbiologist and Infection Control Officer at Saifee Hospital, Mumbai for 9.5 years and now as Head

Microbiology and Infection Control Officer at Reputed Hinduja Hospital, Mumbai India. He has delivered many lectures in India and China, Sydney and Vitebsk.

drjainsachin@gmail.com

Sachin H Jain, J Community Med Health Educ 2018, Volume 8

DOI: 10.4172/2161-0711-C4-041