medical-imaging-2016_posters-accepted-abstracts

10 / 11

Page 69
Medical Imaging 2016
October 20-21, 2016
Volume 5, Issue 5(Suppl) OMICS J Radiol
ISSN: 2167-7964 ROA, an open access journal
conferenceseries .com
October 20-21, 2016 Chicago, USA
International Conference on
Medical Imaging & Diagnosis
OMICS J Radiol 2016, 6:5(Suppl)
3D MR imaging for navigational guidance: Correlation with MEG
Glenn H Roberson
The University of Alabama at Birmingham, USA
From November 2012 to October 2015, 163 patients at The University of Alabama at Birmingham (UAB) were studied with
Functional Magnetic Resonance (fMR) & Diffusion Tensor Imaging for preoperative surgical planning or seizure disorder
management. Presurgical planning included MR perfusion scans for regional blood flow analysis. 30+ of these had concurrent
Magnetic Encephalographic (MEG) for eloquent speech lateralization. The processing of data was performed in a dedicated
Brain Lab utilizing 3D analysis with a variety of 3D work stations. Images are then sent to the OR for navigation guidance.
Comparisons of results, contributions and relative value of these modalities will be presented. Potential pit falls and errors are
analyzed.
Stain-free histopathology of cancer
Haohua Tu
University of Illinois at Urbana-Champaign, USA
Histopathology, whether visualizing microstructure or selectively labeling molecules with special stains, has a long history
of development and maturation, and has been instrumental in biological or clinical laboratories for basic research and
in hospitals for disease diagnosis/screening. To avoid the artifacts associated with sample freezing, fixation, and staining
(labeling), we develop a nonlinear penta-model spectro-microscopy to critically complement or potentially eliminate stained
histology and histopathology. This technique requires a shift of focus from manipulating matter (the biological sample)
to instead manipulating the optical waves (via customized excitation and signal detection) in order to generate molecular
contrast. Instead of using the exogenous labeling agents in conventional optical microscopy to “physically” (invasively) label
the chemical substances of interest; we initiate the use of rapidly switchable light excitation/detection channels to virtually
“label” these chemical substances. Thus, the biological sample can be visualized in its physiologically authentic condition
without sacrificing either molecular specificity or high spatial resolution. This technique is implemented in a programmable
microscope requiring minimum optical realignment, so that a biologist or pathologist with no laser training can in the future
selectively display a specific endogenous molecule (or molecular structure) on the computer screen by programming the
excitation, or instantly compare the displayed molecule distribution with a different one by reprogramming the excitation.
Using breast cancer as a prototypical application, we have imaged the well-known events in tumor microenvironment,
including angiogenesis, lymphangiogenesis, extracellular matrix remodeling, non-native cell recruitment, extracellular vesicle
up-production and switched metabolism toward biosynthesis. This allows us to identify early and quantifiable biomarkers in
breast cancer development.