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Volume 6
Journal of Infectious Diseases & Therapy
ISSN: 2332-0877
Infection Prevention 2018
December 06-07, 2018
December 06-07, 2018 | Valencia, Spain
14
th
World Congress on
Infection Prevention and Control
Phage and aldehyde work in synergy to control
Xanthomonas
infection
Marina Papaianni
1
, Sheridan Lois Woo
2,3
, Francesco Vinale
3
, Maria Luisa Tutino
4
, Ermenegilda Parrilli
4
, Maria Michela Corsaro
4
and
Rosanna Capparelli
1
1
Department of Agricultural Sciences, University of Naples Federico II, Portici (NA), Italy
2
Department of Pharmacy, University of Naples Federico II, Naples, Italy
3
National Research Council, Institute for Sustainable Plant Protection, Portici (NA), Italy
4
Department of Chemical Sciences, University of Naples Federico II, Naples, Italy
X
anthomonas campestris pv. campestris (Xcc) is a Gram-negative bacterium that causes black rot, one of the most
important diseases of vegetable brassica crops worldwide. The use of bacteriophages for the control of vegetable diseases is
a sector of growing interest, providing more advantages than the use of chemicals in agriculture. In this study, we isolated and
characterized a lytic bacteriophage from the soil, capable of reducing Xcc infection. We evaluated the antimicrobial activity of
the phage, and its possible direct administration to the plant xylem. Further, tests were performed both in in vivo and in vitro
experiments to assess the activity of the bacteriophage in association with several anti-biofilm molecules, such as a long-chain
fatty aldehyde and its analogs, that differed in the length of the aliphatic chain, obtained from an Antarctic Pseudoalteromonas
haloplanktis. We demonstrated that the synergism between the bacteriophage and anti-biofilm molecules could be the most
effective way to breakdown the biofilm and control Xanthomonas infection.
marina.papaianni@unina.itJ Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C6-054