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Volume 6

Journal of Infectious Diseases and Therapy

ISSN: 2332-0877

Infection Congress 2018

March 01-02, 2018

March 01-02, 2018 Berlin, Germany

5

th

International Congress on

INFECTIOUS DISEASES

Correlation between abscess size and liver function tests in cases of liver abscess

Vineet Jain

Hamdard Medical College, India

Background:

Liver abscess has shown a major change in demographics, etiology, diagnosis, and treatment over the past 100

years. The modern diagnostics like ultrasound and computed tomography to locate and drain the abscess have reduced the

mortality to 2-12%. However, due to the complications of liver abscess especially the amebic ones the morbidity is still high.

This study aims to study the correlation of various LFT parameters with abscess volume for early detection of high risk patients

and early treatment thus reducing morbidity.

Methods:

The study was conducted over a period of six months on 50 patients of liver abscess. History and physical examination

was done. All patients were subjected to complete hemogram, liver function test, coagulation profile (PT/INR) and USG

abdomen. The data was recorded and compiled in excel sheets and analyzed using correlation coefficient (R) method.

Results:

The mean age of the patients was 41.2 years with male preponderance. Amoebic liver abscess (88%) was predominant

over pyogenic liver abscess (12%). Alcoholism (48%), smoking (42%) and diabetes mellitus (18%) are main predisposing

factors in case of liver abscess. Hepatomegaly was found in 88% cases. Elevated ALP, low albumin, increased PT INR points to

the diagnosis of liver abscess. Complications seen were pleural effusion (10%) and ascites (4%). On analysis, liver abscess size

is significantly positively correlated with INR, ALP, liver enzymes, and negatively correlated with serum albumin level.

Conclusions:

Liver abscess size was found to be positively correlated with INR and alkaline phosphatase (ALP), liver enzymes

(SGOT, SGPT) and negatively correlated with serum albumin levels. There was no correlation of abscess size and bilirubin

levels. Hence, LFT can be used to estimate the liver abscess size and predict the severity and prognosis of patient.

References

1. Meddings L, Myers R P, Hubbard J, Shaheen A A, Laupland K B and Dixon E, et al. (2010) A population-based study of

pyogenic liver abscesses in the United States: incidence, mortality, and temporal trends. Am J Gastroenterol. 105:117-

24.

2. Tsai F C, Huang Y T, Chang L Y and Wang J T (2008) Pyogenic liver abscess as endemic disease, Taiwan. Emerg Infect

Dis. 14:1592-600.

3. Rahimian J, Wilson T, OramV and Holzman R S (2004) Pyogenic liver abscess: recent trends in etiology and mortality.

Clin Infect Dis. 39:1654-9.

4. Channanna C, Rehman F U, Choudhuri B and Patil A (2014) A clinical study, diagnosis and management of Liver

Abscess at VIMS, Bellary. J Evidence Based Med Health Care. 1:668-85.

Biography

Vineet Jain is an Associate Professor at Hamdard Medical College, New Delhi, India. He has an experience of eight years post MD. His special interest has always

been towards Infectious Diseases. He believes that all infectious disease if diagnosed in time and managed appropriately can lead to a drop in mortality. So lot of

my research work is focused on understanding various aspects of infections.

dr.vineet83@yahoo.in

Vineet Jain, J Infect Dis Ther 2018, Volume 6

DOI: 10.4172/2332-0877-C1-039