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Volume 5, Issue 2 (Suppl) J Infect Dis Ther 2017
ISSN: 2332-0877, JIDT an open access journal Infection Congress 2017
May 11-12, 2017
Page 24
Notes:
conferenceseries.com
May 11-12, 2017 Barcelona, Spain
4th International Congress on
Infectious Diseases
Ashok Rattan, J Infect Dis Ther 2017, 5:2 (Suppl)
Prevalence of human papillomavirus genotypes in UAE
Infection with human papillomavirus is the cause of cervical cancer which is one of the leading causes of death in women.
Infection is common in developing countries. For primary prevention, vaccines are available. For secondary prevention
cytological examination has been recommended which has recently been modified to contesting with molecular detection of
virus. Information on genotype distribution in UAE is scanty. We used a multiplex PCR test (Seegene, South Korea) to examine
simultaneously cytological examination and human papillomavirus (HPV) genotype. Study was carried out to document the
prevalence of genotypes in women attending clinics for routine screening. A total of 178 were included in the analysis. Sample
for Pap smear or liquid-based cervical cytology carried out. For persons submitting Pap smear, an additional sample in eNAT
was collected for HPV detection and genotyping while if Thin Prep LBC was available, the fluid was used. Of the 178 samples
tested for HPV, 74 were from women under 30 years of age and 104 from those over 30 years, the age of persons studied
ranged from 18 to 65 years. 79 HPV genotypes belong to 20 different genotypes were identified from 60 patients. 48 were Hr
HPV genotypes and 31 were lr HPV. 33 were from persons below 30 years of age and 46 were from women over 30 years of
age. The high risk genotype 16 was commonest (12) while lr genotype 42 (8), lr 6 (7) and lr 61 (6) were next in frequency. Hr
genotype 18 (4) was fourth among the high risk genotypes after 52 (5) and 53 (5). Other hr genotypes detected were 66 (4), 68
(4) and 39 (4). 32 women were infected by one genotype while dual infection was observed in 12; multiple genotypes (three
or more) were detected in seven women. Using the dual strategy of primary prevention by vaccination of females below 25
years and secondary prevention of five yearly screening by contesting, it is conceivable to have zero cervical cancer by 2020
in UAE, thus preventing a preventable cancer and providing the best preventive healthcare in the world.
Biography
Ashok Rattan has expertise in Microbiology, Immunogenetics and Molecular Biology and held important positions in academics (JN Medical College, Aligarh; AIIMS, New
Delhi; Sharjah Medical College and Mahatma Gandhi Medical University, Jaipur); in industrial research (Ranbaxy New Drug Discovery and Fortis Clinical Research Ltd)
and in diagnostic labs (Religare SRL Diagnostics and Star Metropolis). He has published over 100 research papers in peer reviewed international journals. He has contrib-
uted more than a dozen chapters in different books and has conducted workshops on WHONET in all nine SEARO countries.
Ashok Rattan
Pathkind Diagnostics Pvt Ltd, New Delhi, India