2 / 4
Page 63
conferenceseries
.com
Volume 7
Journal of Hypertension: Open Access
ISSN: 2167-1095
Hypertension 2018
September 10-11, 2018
September 10-11, 2018 | Zurich, Switzerland
4
th
International Conference on
Hypertension & Healthcare
The relationship betweenMTHFRC677T gene polymorphism and essential hypertension in a sample
of an Algerian population of the Oran city
Asma Amrani-Midoun
1
, Soto Romuald Kiando
2,3
, Cyrielle Treard
2,3
, Xavier Jeunemaitre
2,3,4
and
Nabila Bouatia-Naji
2,3
1
University of Oran, Algeria
2
INSERM, France
3
Paris-Descartes University, France
4
AP-HP, France
Background:
Many studies have investigated the role of 5, 10-methylenetetrahydrofolate reductase(MTHFR) C677T gene
polymorphism in essential hypertension (EH), but with conflicting results.
Aim:
To determine the eventual association between 5,10-methylenetetrahydrofolate reductase(MTHFR) C677T gene
polymorphism and hypertension in a sample of Algerian population from the Oran city.
Methods:
A case-control study has been performed in 154 subjects including 82 hypertensives defined as subjects with elevated
systolic blood pressure SBD≥140mmHg and or sustained diastolic blood pressure DBP≥90mmHg, and 72 normotensive
subjects. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) was used to
detect the MTHFR C677T variant.
Results:
We observe no significant differences between allelic and genotypic frequencies between cases and controls for C677T
polymorphism (OR=1.51, 95% CI= 0.89-2.56, P=0.13). Analyses adjusted for age, sex and body mass index improved the
association level, though the association was still not significant (30% vs. 22%, OR=1.75, 95% CI= 0.95-3.24, P=0.07).
Conclusion:
This work showed that genetic polymorphism related to the MTHFR gene (C677T) is not associated with the risk
of hypertension in this sample of Algerian population. Larger case- control samples are required to clearly assess the role of
this genetic variant in EH.
dr.asma.amrani@gmail.comJ Hypertens (Los Angel) 2018, Volume 7
DOI: 10.4172/2167-1095-C1-006