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Volume 8, Issue 5 (Suppl) J Clin Exp Cardiolog
ISSN: 2155-9880 JCEC, an open access journal
Page 29
Notes:
conferenceseries.com
May 22- 24, 2017 Osaka, Japan
World Heart Congress
Heart Congress 2017
May 22- 24, 2017
Visceral obesity, adiponectin and atherosclerosis
Although cholesterol, especially LDL-cholesterol has been considered to be a major risk factor of atherosclerosis and
cholesterol lowering drugs such as statins has been valued highly for the prevention of cardiovascular disease in the
clinical field of all over the world, residual risks such as non-cholesterol dyslipidemia, diabetes mellitus and hypertension,
especially clustering of these risks has been also known to contribute to the occurrence of cardiovascular disease. Many
epidemiological studies has revealed that obesity, especially visceral obesity may induce the development of diabetes mellitus,
hypertension and dyslipidemia and the clustering of these risks may become strong risks of cardiovascular disease. In this
lecture, I will show an important role of visceral fat accumulation in the development of a variety of obesity-related disease
including cardiovascular disease based on our clinical studies using CT scan and also discuss the mechanism of these disorders
by focusing on adipocytokines, adipose tissue-derived bioactive substances especially, adiponectin which was discovered
from human adipose tissue by our group in 1995. Adiponectin is a unique collagen-like protein which has anti-diabetic, anti-
atherogenic function as well as anti-inflammatory function. I would like to show that hypoadiponectinemia caused by visceral
fat accumulation is a key mechanism of a variety of obesity-related diseases such as DM, hypertension and lipid disorders and
also directly cardiovascular disease.
Biography
Yuji Matsuzawa has completed his graduation from Osaka University Medical School in 1966 and joined a research group of Lipid Research Laboratory at Osaka
University in 1969. He became Professor of the second Department of Internal Medicine of Osaka University in 1991, until 2003 when he moved to Sumitomo
Hospital as Director and Emeritus Professor of Osaka University. He has long worked on hyperlipidemia and obesity. He has discovered several novel disease
entities such as "Autoimmune hyperchylomicrolemia" and "Hyper HDL cholesterolemia caused by CETP deficiency". He was also interested in body fat distribution
with respect to morbidity. He developed the method for fat analysis using CT scan and established the concept named visceral fat syndrome in which cardiovascular
risks cluster by visceral fat accumulation. He also investigated biological characteristics of adipose tissue and found that adipose tissue abundantly expressed
bioactive substances. During these works, he discovered "adiponectin", which may be one of key players in the mechanism of obesity-related diseases. He is
currently the President of International Atherosclerosis Society.
Yuji Matsuzawa
Sumitomo Hospital and Osaka University, Japan
Yuji Matsuzawa, J Clin Exp Cardiolog 2017, 8:5 (Suppl)