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Volume 5, Issue 3 (Suppl) Mod Chem Appl, an open access journal
ISSN: 2329-6798 Global Chemistry 2017
September 04-06, 2017
September 04-06, 2017 | London, UK
5th Global Chemistry Congress
Encapsulation of β-cyclodextrin with vitamin-B and vitamin-C molecules
Mahendra Nath Roy
North Bengal University, India
We need vitamin B and vitamin C every day for our growth, but if we take them in surplus/less amounts, our growth will
be hampered. If these vitamins are taken into our body in encapsulated form, body takes these vitamins according to its
requirements and the growth will be normal. Encapsulation of the vitamins is very important to protect these important bio-
molecules from external hazards, i.e., oxidation, sensitization, photolytic cleavage etc.; for the regulatory delivery of necessary amount
of vitamin at the targeted site for a period of time efficiently and precisely and; to prevent overdose. In this work, encapsulation
of β-cyclodextrin with two vitamins namely, nicotinic acid and ascorbic acid in aqueous medium have been explored by reliable
spectroscopic, physicochemical and calorimetric methods as stabilizer, carrier and regulatory releaser of the guest molecules. Stereo-
chemical nature of the inclusion complexes has been explained by 2D NMR spectroscopy. Surface tension and conductivity studies
further support the inclusion process. Isothermal titration calorimetric studies have been performed to determine the stoichiometry,
association constant and thermodynamic parameters with high accuracy. The outcomes reveal that there is a drop in ∆SO, which is
overcome by higher negative value of ∆HO, making the overall inclusion process thermodynamically favorable. Hence, this exclusive
study describes that the inclusion complexes can be used as controlled delivery systems in the field of modern biomedical sciences.
Biography
Mahendra Nath Roy is the Head and Professor in Department of Chemistry at University of North Bengal, India. His research interests are in the areas of “Host-
guest inclusion complexes, ionic liquids, solution thermodynamics and polymer chemistry”. He reviewed 28 PhD thesis and many referred research papers and
authored over 200 research articles and books in Chemistry. He has received award of One Time Grant under Basic Scientific Research from University Grants
Commission, Prof. Suresh C Ameta Award from Indian Chemical Society and has been recently awarded with CRSI Bronze Medal 2017 by Chemical Research
Society of India for his excellence in chemical research throughout his career.
Mahendra Nath Roy, Mod Chem Appl 2017, 5:3(Suppl)
DOI: 10.4172/2329-6798-C1-005