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Gastroenterology 2016
September 12-14, 2016
Volume 6, Issue 5(Suppl) J Gastrointest Dig Syst 2016
ISSN:2161-069X JGDS, an open access journal
conferenceseries .com
September 12-14, 2016 Atlanta, USA
7th Global Congress on
Gastroenterology & Endoscopy
Frequency of h. pylori causing gastritis and peptic ulcer disease in pediatric population
Sonia Shaid
Karachi Medical and Dental College, Pakistan
Objective: To determine the frequency of H.pylori infection causing gastritis and peptic ulcers in children and complications
related to it.
Introduction: Helicobacter pylori is a gramnegative, spiral organism that colonizes the gastric mucosa and causes primary
antral gastritis and peptic ulcer disease. Helicobacter pylori infection is a common problem in pediatric practice, and its
acquisition is related with poor socioeconomic conditions. The possible routes of transmission are feco–oral, oral–oral and
gastro–oral. H. pylori causes chronic inflammation ( gastritis) by invading the lining of the stomach and thus can lead to
ulcer formation. When the infection leads to an ulcer, symptoms may include abdominal pain, excessive burping, feeling
bloated, nausea or vomiting, lack of appetite and unexplained weight loss. H. pylori infections can lead to peptic ulcers, but the
infection or the ulcer itself can lead to more serious complications these include; interna bleeding, which can happen when a
peptic ulcer breaks through your blood vessel; obstruction, which can happen when an ulcer blocks the food from leaving your
stomach;perforation, which can happen when an ulcer breaks through your stomach wall and peritonitis, which is an infection
of the peritoneum, or the lining of the abdominal cavity
Methodology: This cross‐sectional study was conducted from July 2014 ‐ July 2016. Pediatric patients under 12 years of age
were recruited in this study. A history and examination form designed from an application “Forms”,particularly for the study.
Children were examined and endoscopic biopsy was done to find out the extent of infection. For data analysis SPSS 16.0
software was used.
Results: Out of 489 subjects, mainly mucosal erosions were revealed at endoscopy in 361 subjects (73.82%). Gastritis was found
in 272 subjects (75.3%), of whom 266 (54.4% of the total) were found to be infected with H. pylori. Gastritis and H. pylori
were noted in both the antrum and corpus in 75% of those infected children. In complications, internal bleeding was found in
35.67% children, obstruction in 21.45%, perforation in 19.7% and peritonitis in 23.18% Stepwise logistic regression analysis
revealed that the relative risk for H. pylori infection associated with gastritis was 5.8 (95% confidence interval), whereas the
relative risk for peptic ulcer was 6.5 (95% confidence interval).
Conclusion: The main predisposing factors identified in these studies were low socioeconomic status and poor hygiene. The
results may explain why the rate of infection is so high in poorer countries and in socioeconomic groups characterized by
crowded living conditions, poor sanitary conditions, and lack of clean water.Endoscopy also allows determination of the
severity of gastritis with biopsies as well as the presence of ulcers.
Biography
Sonia Shahid is a final year M.B.B.S student of Karachi Medical and Dental College, Karachi Pakistan. She has been a part of several national and international
researches and many are ongoing. She has attended several national and international seminars and conferences. She has good knowledge of clinical practices
and protocols in variety of settings. Sonia is an inquisitive student with a passion for education as a power for change and improvement in the healthcare field of
her country and is very ambitious in pursuing her career.
Sonia Shaid, J Gastrointest Dig Syst 2016, 6:5(Suppl)