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Gastro 2016
August 11-12, 2016
Volume 6, Issue 4(Suppl) J Gastrointest Dig Syst 2016
ISSN:2161-069X JGDS, an open access journal
conferenceseries .com
August 11-12, 2016 Birmingham, UK
6th Global Gastroenterologists Meeting
Doaa Helmy, J Gastrointest Dig Syst 2016, 6:4(Suppl)
Prevalence of ischemic heart diseases in patients with chronic hepatitis C infection among Egyptian
population
Doaa Helmy
Mansoura University, Egypt
Introduction: In Egypt, the situation is very critical. Hepatitis C virus constitutes an epidemic in Egypt which is having the
highest prevalence in the world. In all other countries, the prevalence of HCV constitutes 1% to 2% of the population. There
are a few exceptions where the prevalence of HCV is 3%. In Egypt however, the prevalence of HCV is 14.7%. The association
between HCV infection and Coronary Artery Diseases (CAD) is less clear with different studies showing conflicting results, a
small number of studies have reported no association between HCV infection and CAD. On the other hand other studies have
reported an increased risk of CAD in HCV patients.
Aim: The aim is to study the relation and severity of CAD in patients with chronic HCV infection.
Methods: This cross sectional study was conducted during the period from June 2013 to September 2015 inMedical Specialized
Hospital (MSH), Mansoura University, Egypt. The study included 200 patients with chronic HCV who attended hepatitis
virology clinic and were referred to cardiology clinic for evaluation of their cardiac complaint. An informed consent was
obtained from all patients and the protocol was approved from the Ethical Committee of Faculty of Medicine, Mansoura
University. Chronic HCV was defined by the presence of anti-HCV antibodies and measurable serum HCV-RNA by PCR >15
IU/ml for 6 months, according to FibroScan, F0-F1: Absent or minimal liver fibrosis; F2: Significant liver fibrosis has occurred
and spread inside the areas of the liver including blood vessels; F3: Severe liver fibrosis which is spreading and connecting to
other liver areas that contain fibrosis; F4: Cirrhosis or advanced liver fibrosis. Based on the result of the previous coronary
angiography and revascularization procedure it was reviewed that, the severity of CAD is based on the severity of coronary
lesion and the location of this lesion according to the Gensini score. Score (1): for lesions 1%–25% stenosis; Score (2): for
lesions 26%–50% stenosis; Score (4): for lesions 51%–75% stenosis; Score (8): for lesions 76%–90% stenosis; Score (16): for
lesions 91%–99% stenosis and Score (32): for total occlusion.
Results: Data were analyzed by SPSS version 21. ANOVA test was used to compare mean of more than 2 groups; while Kruskal
Wallis H Test was used for comparison of median of more than two groups. Patients were classified into 3 groups according
to severity of liver fibrosis assessed by FibroScan, Group 1 (34 patients) constitutes 17% of the studied group, Group 2 (59
patients) constitutes 29.5% of the studied group and Group 3 (107 patients) constitutes 53.5% of the studied group. Patients
with non-significant lesions were 21 patients representing (28.4%), while patients with significant lesion were 53 patients
representing (71.6%). According to the number of vessels affected with significant lesions, patients who showed single vessel
disease were 20 patients, with double vessel disease were 18 patients, and with triple vessel disease were 15 patients. Patients in
Group 2 and Group 3 had statistically more severe atherosclerosis regards to Gensini Score (p: 0.006)
Biography
Duaa Helmy is serving as an esteemed researcher in Mansoura University, Egypt. She is the recipient of numerous awards for her expert research works in related
fields. Her research interests reflect in her wide range of publications in various national and international journals.