gastro-congress-2019-posters-abstracts

49 / 60

Page 49
conferenceseries.com
Volume 09 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Gastro Congress 2019
July 08-09, 2019
July 08-09, 2019 | Zurich, Switzerland
14th Euro-Global Gastroenterology Conference
Prognostic impact of preoperative prognostic nutritional index in resected advanced gastric cancer: A
multicenter propensity score analysis
Alpha I Balde
Southern Medical University, China
Background: Advanced gastric cancer (AGC) causes debilitating malnutrition and leads to deterioration of the
immune response. However, the concept of the prognostic nutritional index (PNI) is controversial when applied to
patients with AGC.
Aim: The aim of the present study was to evaluate the effect of the PNI after gastrectomy in patients with AGC.
Materials & Methods: A multicenter retrospective study was conducted using propensity score matching (PSM) in
gastric adenocarcinoma patients who underwent resection via laparoscopic or open surgery between 2014 and 2017.
To overcome selection bias, we performed 1:1 matching using five covariates.
Results: The resectionmargins (P<0.001) and LNM (P=0.004) were significantly different between the two groups. In
univariate analysis, poor tumor differentiation (P=0.038) (R1+R2, P=0.004), vascular and neural invasion (P<0.001),
and a PNI<50 (P<0.001) were associated with poor recurrence-free survival (RFS). In multivariate analysis, a
PNI<50 (Hazard ratio (HR), 12.993; P<0.001) was a risk factor for RFS. Univariate analysis for overall survival (OS)
revealed that a PNI<50 (P<0.001) (R1+R2, P=0.006) and vascular and neural invasion (P<0.001) were risk factors.
In subsequent multivariate analysis, a PNI<50 (HR, 24.501; P<0.001) was a significant risk factor for OS. Clinical
assessments performed during a 12.34 (±5.050) month follow-up revealed that OS (P<0.001) and RFS (P<0.001)
were worse in patients with a low PNI (<50) than in matched patients with a high PNI.
Conclusion: A low PNI is a strong predictor of unfavorable RFS and OS in patients with AGC.
J Gastrointest Dig Syst 2019, Volume 09