gastro-congress-2018-keynote

3 / 8

Volume 8 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Gastro Congress 2018
August 20-21, 2018
Page 41
Notes:
conferenceseries.com
August 20-21, 2018 | Rome, Italy
13th Euro-Global
Gastroenterology Conference
Giovanni Gasbarrini, J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C5-075
Gut Microbiota: An epochal revolution
Few data exist on differences in gut microbiota composition among principal gastrointestinal diseases. We evaluated the
differences in gut microbiota composition among uncomplicated diverticular disease (DD), IBS and IBD patients. DD, IBS
and IBD patients along with healthy controls (CT) were enrolled in our Italian GI outpatient clinic. Stool samples were collected.
Microbiota composition was evaluated through a metagenomic gene-targeted approach. GI pathology represented a continuous
spectrum of diseases where IBD displayed one extreme while healthy controls displayed the other. Among Phyla, Biplot PC2/PC3
and dendogram plot showed major differences in samples from IBS and IBD. DD resembled species CT composition, but not for
Bacteroides fragilis. In IBS, Dialister spp and then Faecalibacterium prausnitzii were the most representative species. UC showed
a reduced concentration of Clostridium difficile and an increase of Bacteroides fragilis. In CD, Parabacteroides distasonis was
the most represented, while Faecalibacterium prausnitzii and Bacteroides fragilis were significantly reduced. Each disorder has its
definite overall microbial signature, which produces a clear differentiation from the others. On the other side, shared alterations
constitute the “core dysbiosis” of GI diseases. The assessment of these microbial markers represents a parameter that may complete
the diagnostic assessment.
Biography
Giovanni Gasbarrini was President of the Italian Society of Alcology and Member of the Board of Directors of the Italian Society of Gastroenterology, of the Italian
Society of Internal Medicine, from which he was awarded the title of Member of Honor. He is the founder and President of the “Club del Tenue” and of
the “FONCRE” (Operative Cancer Rectus-Colon), and currently the corporate framework for digestive diseases (Club del Tenue, FONCRE, Hp Italian Section,
Intestinal Motility). He was Vice-President of the International Association of Surgeons & Gastroenterologists. He was President and is now a Member of the European
Helicobacter Study Group (of which the Italian section is also the President); he was President of EAGEN (European Associate Gastroenterol, Nutrition) and
is currently past-President of EAGEN. He is a member of over 15 Italian and International Scientific Societies (Italian Society of Internal Medicine -Italian
Geriatrics Society -Italian Gastroenterology Society - Italian Electronic Microscopy Society -Italian Society of Alcology - European Society Liver Study - French Society
of Gastroenterology.
Giovanni Gasbarrini
Catholic University of Rome, Italy