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Volume 8 Journal of Clinical & Experimental Pathology
ISSN : 2161-0681 Euro Pathology 2018 | Hematologic Oncology 2018
June 20-21, 2018
Page 42
Notes:
conferenceseries.com
15 th EUROPEAN PATHOLOGY CONGRESS
&
LEUKEMIA AND HEMATOLOGIC ONCOLOGY
June 20-21, 2018 | Paris, France
14th International Conference on
JOINT EVENT
Marie-Pierre Junier, J Clin Exp Pathol 2018, Volume 8
DOI: 10.4172/2161-0681-C1-044
A coupling between a neurotransmitter’s metabolism and epigenetic regulations promotes intra-tumor
heterogeneity in glioma
C ell populations with differing proliferative, stem-like and tumorigenic states co-exist in most tumors and especially
malignant gliomas. Whether metabolic variations can drive this heterogeneity by controlling dynamic changes in cell states
is unknown. We addressed this question by combining cell biology and neuropathological approaches. Metabolite profiling of
human adult glioblastoma stem-like cells upon loss of their tumorigenicity, followedby genetic andpharmaceuticalmanipulations
highlighted a novel signaling module that couples the catabolism of the GABA neurotransmitter and the formation of DNA
epigenetic marks. This signaling module was efficient in adult glioblastoma cells with varying molecular profiles, along with
cells from pediatric pontine gliomas. Importantly, we verified the relevance of all our findings in the context of the human
pathology, using bioinformatics analyzes of patient-derived data at the tissue and single cell level, and immunohistochemical
and metabolite analyzes of patients’ tumor samples. These results highlight unexpected levels of heterogeneity among the tumor
cells, and support an active participation of metabolic variations in the genesis of tumor heterogeneity.
Biography
Marie-Pierre Junier’s interest in brain neoplasms developed as a natural extension of fundamental research studies aiming at deciphering the role of neuron-glia interactions
during development and neurodegenerative diseases. Following studies of the role of troubles of glial cell differentiation in cancerous transformation, she created with
Dr. H Chneiweiss the team “Glial plasticity and neuro-oncology” located in the Neuroscience laboratory of the Institute of Biology Paris Seine Institute (IBPS). The team
project questions the dynamics of tumor cell functional heterogeneity, and its impact on malignant glioma growth.
Marie-Pierre Junier
IBPS-Neuroscience Paris Seine, France
Sorbonne Universities, France