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Volume 7, Issue 4 (Suppl)
J Clin Exp Pathol, an open access journal
ISSN: 2161-0681
Euro Pathology 2017
August 02-03, 2017
Page 51
Notes:
conference
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EUROPEAN PATHOLOGY CONGRESS
August 02-03, 2017 Milan, Italy
Sergey V Brodsky, J Clin Exp Pathol 2017, 7:4(Suppl)
DOI: 10.4172/2161-0681-C1-036
Anticoagulant related nephropathy: Lessons from patients and experimental animals
W
e have recently identified a new clinical syndrome in patients receiving warfarin for anticoagulation. This syndrome has been
named warfarin-related nephropathy (WRN), and patients with chronic kidney disease (CKD) appear to be particularly
susceptible. WRN is defined as an acute increase in INR to greater than 3.0, followed by evidence of acute kidney injury (AKI) within
a week of the INR increase, defined as a sustained increase in serum creatinine of greater than or equal to 0.3 mg/dl. The AKI cannot
be explained by any other factors, and the kidney biopsy demonstrates extensive glomerular hemorrhage with tubular obstruction by
red blood cells. Beyond AKI, WRN is a significant risk factor for mortality within the first two months of diagnosis and it accelerates
the progression of CKD. CKD is the most important risk factor for WRN and in CKD patients on warfarin who experience an
increase in INR to >3.0, WRN is seen in 33–37%of the patients. Recent evidences suggest thatWRN-like syndromes are not confined
to anticoagulation with warfarin, but may be seen with the newer oral anticoagulants coming into clinical use. We have thus coined
the term anticoagulant-related nephropathy (ARN) to encompass the possibility that other anticoagulant drugs may put patients at
risk. We developed an animal model to study ARN. 5/6 nephrectomy rats treated with warfarin or dabigatran showed increase in
serum creatinine and morphology in the kidney similar to humans. Nephrologists and renal pathologists should be aware about this
serious complication of anticoagulation therapy.
Biography
Sergey V Brodsky has completed his MD and PhD in 1992 and 1995, respectively from North Ossetian Medical Academy in Russia. His research interests include renal
pathology, renal physiology, vascular biology and angiogenesis.After finishing his Residency inAnatomic Pathology and a fellowship in Renal Pathology in 2009, he currently
works as a Renal Pathologist at Ohio State University, USA. He has published more than 95 papers in peer-reviewed journals and book chapters.
sergey.brodsky@osumc.eduSergey V Brodsky
Ohio State University, USA