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Volume 8, Issue 3 (Suppl) J Clin Cell Immunol, an open access journal
ISSN: 2155-9899 Euro Immunology 2017
June 29-July 01, 2017
June 29-July 01, 2017 Madrid, Spain
8th European
Immunology Conference
Chorea and aphasia as a manifestation of SLE in an adolescent female: Case report
Ortega-Alonzo S E, Portillo-Palma P A, Rubio-Pérez N E and Rodríguez-Pérez M L
Monterrey Institute of Technology and Higher Education, México
Background: Systemic Lupus Erythematosus (SLE) is a chronic, inflammatory and autoimmune disease with multi-systemic
involvement. Children represent 10-20% in the general population and neuropsychiatric symptoms have a prevalence of 17-70%.
Objective: Objective of the study was to describe the clinical presentation and neurological manifestations in a pediatric patient with SLE.
Methods: We present the case of a 15 year female with 3 week history of movement disorder, dysarthria and emotional liability.
Laboratory and imaging studies were performed and a diagnosis of Sydenham’s chorea was established. Following 4 weeks of
treatment, she developed arthritis and aphasia.
Results: Radiologic evaluation did not show any disturbances, general laboratories were normal, immunological profile reported
anti-nuclear antibodies with a title of 1:640, fine speckled pattern, and lupus anti-coagulant reported 2.18.
Conclusion: Diagnostic evaluation of SLE in children represents a challenge due to its clinical heterogeneity; the time related to
adding signs during life and the wide severity of symptoms among pediatric population. Neurologic and psychiatric manifestations
represent one common and severe evolution in SLE. Choreic movements occur in less than 5% of patients and may precede the
accurate diagnosis for months and years, before the development of the whole clinical picture.
J Clin Cell Immunol 2017, 8:3(Suppl)
DOI: 10.4172/2155-9899-C1-037
Case with hypersensitivity pneumonia
Savas Gegin and Kamil Furtun
Samsun Chest Diseases and Thoracic Surgery Hospital, Samsun, Turkey
Introduction: Hypersensitivity pneumonia is an immunology based lung disease caused by antigens that are inhaled, characterized
by peripheric airway lymphocytic infiltration and granulomatous lesions that surround interstitium. It is an allergic lung disease
that develops as a result of the inhalation of organic dust. The most common form of this lung disease is pigeon fancier disease and
it develops as a result of the inhalation of some kinds of organic antigens. Pigeon fancier disease is a hypersensitivity pneumonia
that develops as a result of the stool of winged animals, serum and feather antigens. Not only pigeons in the first instance, but also
the other winged animals cause hypersensitivity pneumonia. The most important thing is not only to diagnose the clinical findings
and radiologic symptoms, but also to detect the exposure to such animals. Here, we are presenting the case that develops the pigeon
fancier hypersensitivity pneumonia and the treatment carried out.
Case: 65 year male patient, a farmer consulted the clinic as a result of having cough and difficulty in breathing. He had suffered from
these problems for two months. In physical examination, saturation via pulse oxymeter was %90. Bilateral rales were diagnosed in
respiration. Blood analysis was non-specific and in lung graphy, rise in nonhomogenous density on bilateral lower and middle zone
was detected. Respiration function test was seen as FVC 1.52 lt. %41 FEV1 1.52 %50 FEV1/FVC %129. Thoracic CT was carried out.
It was seen that there were areas with distinct common ground glass density, in bilateral lower lobes in CT (Picture 1). It was seen that
the patient had been a pigeon fancier for two months. The patient was diagnosed as having hypersensitivity pneumonia and 40 mg
methyl prednisolone was given to him for treatment. He kept himself away from pigeons from that day on. The dose of steroid was
reduced and finally at the end of the 4th month the patient was no longer given it. Via the control of thoracic CT of the patient, distinct
recovery was detected on ground glass density areas. (Picture 2) After the treatment, distinct clinic recovery was seen.
Discussion: Hypersensitivity pneumonia develops as a result of the inhalation of organic dusts. Though the help of radiologic
symptoms cannot be ignored, the exposure of the patient to such animals has an important role in diagnosing. It is suggested that the
patients who are compatible with clinic and radiologic symptoms of hypersensitivity pneumonia, should also be inspected in terms
of exposure to such animals.