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.com
Volume 7, Issue 5 (Suppl)
Epidemiology (Sunnyvale), an open access journal
ISSN: 2161-1165
Epidemiology 2017
October 23-25, 2017
EPIDEMIOLOGY & PUBLIC HEALTH
October 23-25, 2017 | Paris, France
6
th
International Conference on
PERSISTENT ORGANIC POLLUTANTS IMPAIR INSULIN SECRETORY FUNCTION OF
PANCREATIC BETA-CELLS: HUMANAND IN VITRO EVIDENCE
Yu-Mi Lee
a
, Chae-Myeong Ha
a
, Se-A Kim
a
, Themis Thoudam
a
, Sungmi Park
a
, In-Kyu Lee
a
, Duk-Hee Lee
a
, Dae-Jung Kim
b
, Hyeon-Chang Kim
c
, Hyo-Bang
Moon
d
and
Young-Ran Yoon
a
a
Kyungpook National University, Republic of Korea
b
Ajou University School of Medicine, Republic of Korea
c
Yonsei University College of Medicine, Republic of Korea
d
Hanyang University, Republic of Korea
P
ersitent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have
emerged as a new risk factor of type 2 diabetes (T2D). We evaluated whether chronic exposure to low-dose POPs affects
insulin secretory function of beta-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured
in 200 non-diabetic adults. Mathematical-model-based insulin secretion indices were estimated using a 2-hour 7-sample oral
glucose tolerance test. Insulin secretion by INS1E beta-cells was measured after 48-hour treatment with 3 OCPs or a PCB
mixture. Static second-phase insulin secretion significantly decreased with increasing serum concentrations of OCPs. Adjusted
means were 63.2, 39.3, 44.1, 39.3, 39.7, and 22.3 across six categories of a summary measure of OCPs (Ptrend = 0.02). Dynamic
first-phase insulin secretion remarkably decreased only among insulin-sensitive individuals with increasing concentrations of
OCPs (Ptrend = 0.02); the insulin levels among subjects with high OCPs were about 30% of those with low OCPs. Compared
to OCPs, PCBs showed weaker associations. The decreased insulin secretion by INS1E beta-cells was observed for even 1 pM
OCPs. Our data from human subjects and in vitro cell experiments suggest that chronic exposure to low-dose POPs, especially
OCPs, can induce pancreatic beta-cell dysfunction
Acknowledgement: This work was supported by the Korea Ministry of Environment (MOE) as “the Environmental Health
Action Program (2016001370002).”
Biography
Yu-Mi Lee is an Assistant Professor in the Department of Preventive Medicine, School of Medicine, Kyungpook National University. He was a Clinical Fellow in
Kyungpook National University from 2013 to 2015. He took residency training in Kyungpook National University from 2010 to 2013 and also took MD training at
Kyungpook National University from 2003 to 2009.
yumilee@knu.ac.krYu-Mi Lee et al., Epidemiology (Sunnyvale) 2017, 7:5(Suppl)
DOI: 10.4172/2161-1165-C1-018