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Volume 6, Issue 5(Suppl) Epidemiology (Sunnyvale)
ISSN: 2161-1165 ECR, Open Access
Page 80
Notes:
Epidemiology 2016
October 3-5, 2016
conferenceseries.com
Epidemiology & Public HealthOctober 3-5, 2016|London, UK
4th International Conference on
EXTENDED MOLECULAR EPIDEMIOLOGY OFACUTE GASTROENTERITIS IN
HOSPITALIZED CHILDREN AFTER ROTAVIRUS VACCINE IMPLEMENTATION IN
TAIWAN
Shih-Yen Chena
aChang Gung University College of Medicine, Taiwan
Background: Rotavirus vaccine implementation has changed enteric virus infections in children.
Objective: To investigate the change in viral acute gastroenteritis (AGE) and associated infections in hospitalized children in a
longer time after rotavirus vaccine implementation.
Design: During the period from January 2006 to December 2015, fecal samples from hospitalized children in Chang Gung
Children’s Hospital with AGE were examined for enteric pathogens. Study period was divided into early post-vaccine (2006
Jan.-2010 Dec.) (EPV) and late post-vaccine (2011 Jan. -2015 Dec.) (LPV) periods.
Setting: A tertiary children’s medical center in northern Taiwan.
Results: A total of 905 stool samples were collected from hospitalized patients with AGE including 441 in EPV and 464 in
LPV. In EPV period, enteric pathogens were identified in 318 (72.1%) including 113 (25.6%) rotavirus, 107 (24.3%) norovirus
as major pathogens; In LPV periods, detection ratio of 315 (67.9%) with major infections of 88 (19 %) rotavirus and 107
(23.1%) norovirus. Statistical analysis showed a significantly decreased prevalence of rotavirus infection (P = 0.016) and a
significantly increased prevalence of enteric bacteria infections (P < 0.001). Norovirus has outnumbered rotavirus (23.1% vs
19%) as the most common viral pathogen acute gastroenteritis. Rotavirus genotyping demonstrated a significant decrease of
G1 (P=0.0002) in LPV compared to that of EPV. Norovirus GII.4 were the most predominant genotype in both periods with
the commonest of GII.4 2006 b strain (35 of 59, 59.3%) in EPV and GII.4 2012a Sydney strain (29 of 65, 44.6%) in LPV period.
Among vaccinated patients with AGE, norovirus is the most common etiology and there was relatively lower prevalence
rotavirus infection in LPV with common genotypes of G1, G2, and G3.
Conclusions: In Taiwan, under a suboptimal rotavirus vaccination policy, rotavirus infection caused hospitalization AGE is
definitely decreased and norovirus has replaced rotavirus as the leading cause for hospitalized children with AGE. Enrichment
of rotavirus vaccine coverage, development of norovirus vaccination, and sustained bacterial infections control important for
infection containment and hospital care in Taiwan.
Biography
Shih-Yen Chen is currently an attending physician in the Department of Pediatrics, Chang Gung Children’s Hospital and Chang Gung University, Taoyuan, Taiwan.
He received his Doctor of Medicine degree from Taipei Medical College, and Doctor of Philosophy degree from Chang Gung University College of Medicine.
He obtained his postdoctoral fellowship training from the Division of Pediatric Gastroenterology and Hepatology, Chang Gung Children’s Hospital. His research
interests include pediatric gastrointestinal infection and molecular epidemiology of viral gastroenteritis.
Shih-Yen Chen, Epidemiology (Sunnyvale), 6:5(Suppl)