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Volume 09
Otolaryngology: Open Access
ISSN: 2161-119X
ENT 2019
Craniofacial Surgery 2019
August 15-17, 2019
JOINT EVENT
conferenceseries
.com
August 15-17, 2019 Rome, Italy
&
3
rd
International Conference on
Craniofacial Surgery
4
th
European Otolaryngology-ENT Surgery Conference
Anti-Staphylococcal Humoral Immune Response in Patients with Chronic Rhinosinusitis
Ulrica Thunberg*
1,2
, Svante Hugosson
1,2
, Hans Fredlund
2,3
, Yang Cao
4,5
, Ralf Ehricht
6,7,8
, Stefan Monecke
6,7,9
Elke Müller
6,7
, Susanne Engelmann
6,7,9
, Bo
Söderquist
2,3
1
Department of Otorhinolaryngology, Örebro University Hospital, Örebro, Sweden
2
Faculty of Medicine and Health, Örebro University, Sweden
3
Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden
4
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden
5
Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
6
Abbott (Alere Technologies GmbH), Jena, Germany
7
InfectoGnostics Research Campus, Jena, Germany
8
Leibniz Institute of Photonic Technology (IPHT), Jena, Germany
9
Institute for Medical Microbiology and Hygiene, Technical University of Dresden, Dresden, Germany
S
taphylococcus aureus (S. aureus) can behave both as a harmless commensal and as a pathogen. Its significance in
the pathogenesis of chronic rhinosinusitis (CRS) is not yet fully understood. This study aimed to determine serum
antibody responses to specific staphylococcal antigens in patients with CRS and healthy controls, and to investigate
the correlation between specific antibody response and severity of symptoms. Serum samples from 39 patients with
CRS and 56 healthy controls were analyzed using a protein microarray to investigate the antibody response to S.
aureus specific antigens, with a focus on immunoglobulin G (IgG) directed toward staphylococcal components
accessible to the immune system. Holm-Bonferroni corrections were applied in all analyses. Information about
growth of S. aureus in nares and maxillary sinus was taken from a previous study based on the same individuals.
Clinical symptoms were assessed using a scoring system. IgG antibody levels toward staphylococcal TSST-1 and
LukF-PV were significantly higher in the CRS patient group compared to healthy controls, and levels of anti-TSST-1
antibodies were significantly higher in the CRS patient group with S. aureus in maxillary sinus than in controls. There
were no correlations between the severity of symptoms and levels of serum anti-staphylococcal IgG antibody levels
for LukF-PV and TSST-1. TSST-1 and LukF-PV could be interesting markers for future studies of the pathogenesis
of CRS.
Recent Publications:
1.
Thunberg U, Augustsson I, Hugosson S
2.
Isolated zygomatic fracture is preferably treated by Gillies reposision. It has a given place in the therapeutic
arsenal, acording to an observation study. Läkartidningen. 2010 12-25;107(19-20):1300-3 Swedish PMID:
20556981
3.
Thunberg U, Engström K, Olaison S, Hugosson S. Anterior rhinoscopy and middle meatal culture in acute
rhinosinusitis. J Laryngol Otol. 2013 Nov;127(11):1088-92
4.
Thunberg U, Hugosson S, Monecke S, Ehricht R, Soderquist B. Molecular characteristics of Staphylococcus
aureus associated with chronic rhinosinusitis. APMIS. 2015;123(1):37-44.
5.
Thunberg U, Engstrom K, Olaison S, Hugosson S. Anterior rhinoscopy and middle meatal culture in acute
rhinosinusitis. J Laryngol Otol. 2013;127(11):1088-92.
Biography
Dr. Ulrica Thunberg is specialized in otorhinolaryngology. She has been working in the field since 20 years. and has her main research in rhinology. She is
working at the university hospital of Örebro, Sweden.
ulrica.thunberg@regionorebrolan.seUlrica Thunberg et al., Otolaryngol (Sunnyvale) 2019, Volume 09