14 / 20
Page 83
Volume 09
Otolaryngology: Open Access
ISSN: 2161-119X
ENT 2019
Craniofacial Surgery 2019
August 15-17, 2019
JOINT EVENT
conferenceseries
.com
August 15-17, 2019 Rome, Italy
&
3
rd
International Conference on
Craniofacial Surgery
4
th
European Otolaryngology-ENT Surgery Conference
The Incidence of Thyroid Gland Invasion in Advanced Laryngeal Squamous Cell Carcinoma
Hadi Al-Hakami
KSAU-HS, Jeddah, KSA
Objectives:
To evaluate the frequency of the thyroid gland invasion in patients with advanced laryngeal squamous cell
carcinoma submitted to total laryngectomy and thyroidectomy and to determine whether clinical and pathological
characteristics of laryngeal carcinoma can predict glandular involvement.
Methods:
A retrospective case series with chart review, from March 2009 to January 2018, was undertaken in the
Princess Norah Oncology Center, King Abdul-Aziz Medical City, Jeddah / KSA. An inception cohort of 56 patients
with laryngeal squamous cell carcinoma was considered. Nine cases were excluded. All patients had advanced
stage cancer larynx (clinically T3-T4) and underwent total laryngectomy in association with thyroidectomy. Total
thyroidectomy was performed in all bilateral lesions or if there was suspicion of contralateral lobe involvement.
Hemithyroidectomy was performed in all lateralized lesions. Retrospective histopathologic analysis of thyroid
specimens was subsequently performed. The frequency of thyroid gland invasion was calculated and analysis of
demographic, clinical and pathological characteristics associated with thyroid gland invasion was performed.
Results:
In all, 47 patients underwent total laryngectomy (40 treated with primary laryngectomy and seven treated
with salvage laryngectomy following radiation failure or chemoradiation failure). Hemithyroidectomy was performed
in 42 patients and the total thyroidectomy was performed in five patients. The overall frequency of invasion of the
thyroid gland was 4.3%. Glandular involvement was seen in one advance transglottic squamous cell carcinoma and
one subglottic. In spite of thyroid cartilage invasion in 25.5% of cases detected in the preoperative radiological
imaging, only one case demonstrated microscopic thyroid gland invasion.
Conclusions:
Invasion of the thyroid gland is not a general feature of advanced laryngeal carcinoma. There is no
need for performing thyroidectomy in all total laryngectomy cases. The thyroidectomy may only be required during
total laryngectomy for selected cases of advance transglottic tumors and tumors with subglottic extension more
than10 mm.
Otolaryngol (Sunnyvale) 2019, Volume 09