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Digital Pathology & Pathologists 2016
December 05-06, 2016
Volume 6 Issue 5(Suppl) J Clin Exp Pathol
ISSN: 2161-0681 JCEP, an open access journal
conferenceseries .com
December 05-06, 2016 Madrid, Spain
9th World Digital Pathology & Pathologists Congress
Paul Holvoet, J Clin Exp Pathol 2016, 6:5(Suppl)
Mitochondrial stress in monocytes is reflected in micro-vesicles and associated with metabolic and
coronary artery diseases
Paul Holvoet
Katholieke Universiteit Leuven, Belgium
Obesity’s negative impact on health is well-documented. Health consequences are categorized as being the result of either
increased fat mass (which leads to osteoarthritis, obstructive sleep apnea, social stigma) or an increased number of fat
cells (which contributes diabetes, cancer, cardiovascular diseases). Disease processes increasing risk in association with obesity
are subclinical chronic low-grade inflammation and oxidative stress which are also involved in development of cardiovascular
diseases. For example, recent data suggest that increased oxidative stress in adipose tissue is an early instigator of metabolic
syndrome. Given the number of symptoms and risk factors which characterize metabolic syndrome, the variability in
combinations of three out of five its components, and the variability in treatments and patient responses to treatment of those
symptoms, there remains a need in the art for identifying patients who are at risk for developing metabolic syndrome, T2D,
and/or cardiovascular diseases. In this study we discovered RNA expression patterns related to mitochondrial dysfunction and
oxidative stress in monocytes which were associated with metabolic syndrome and T2D, and identified an at-risk population
for new cardiovascular events in CAD patients. For the first time, we showed that signatures in monocyte-specific micro-
vesicles reflects these in monocytes and have similar predictive properties. We also found that identified gene signatures were
related to obesity and atherosclerosis in mice and pigs.
Biography
Paul Holvoet is a Professor in Biomedicine at the Department of Cardiovascular Sciences at the Catholic University of Leuven. His research focuses on the
interaction between oxidative stress and inflammation in the pathogenesis of metabolic and cardiovascular diseases. He is a Fellow of the European Society of
Cardiology and the American Heart Association. He is first inventor on international patents related to oxidized LDL and gene signatures in monocytes and derived
exosomes. He is also a Co-Founder of Tank™.