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conferenceseries.com
June 19-20, 2017 Philadelphia, USA
14th International Conference on
Clinical and Experimental Dermatology
Volume 8, Issue 4 (Suppl) J Clin Exp Dermatol Res, an open access journal
ISSN:2155-9554 Dermatology 2017
June 19-20, 2017
The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin
pathologies
Sevil Alan
Akdeniz University School of Medicine, Turkey
GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily. GDF-15
is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses,
bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15 is regulated by
p53, has shown antitumorigenic and proapoptotic activities in vivo and in vitro. Also, GDF-15 is involved in skin biology and
histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and
metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and
intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin
fibrosis and malignant lesions of the skin.
Biography
Sevil Alan has received her PhD from Ege University, Turkey during the period of 1993-1999. She completed her Dermatology Residency at the Adana Numune
Education and Research Hospital in Adana, Turkey. Currently, she is working as a Dermatologist in Akdeniz University School of Medicine, Turkey. She is an
Editorial Board Member of journals like SM Dermatology, Dermatology & Pigmentation Disorders, and International Journal of Clinical Dermatology & Research
(IJCDR). She is serving as a Reviewer for journals like JAMA Dermatology, International Research Journal of Public and Environmental Health, International
Medical Journal of Sifa University. She has authored many research articles.
Sevil Alan, J Clin Exp Dermatol Res 2017, 8:4 (Suppl)
DOI: 10.4172/2155-9554-C1-059