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Volume 8
Journal of Alzheimers Disease & Parkinsonism
Dementia 2018
December 13-15, 2018
Page 49
Notes:
December 13-15, 2018 Abu Dhabi, UAE
13
th
Annual Conference on
Dementia and Alzheimer's Disease
Alzheimer’s disease in Saudi subjects of risk with CLU gene ploymoprphiosm and association of APOE
Nouf Al Ghunaim, Amani AlGhamdi, Saba Abdi, Nasser AlDaghri, Mohammed Masoud, Syed Danish Hussain, Kaiser Wani, Mohammed Ansari, TaimMuayqi
King Saud University, Saudi Arabia
A
lzheimer's disease (AD) is a progressive irreversible neurodegenerative disease, characterized by the accumulation of
insoluble extracellular amyloid plaques and intracellular neurofibrillary tangles causing damage and death of surrounded
neurons. This in turn affects memory, attention, and communication of people with AD. The present study was aimed to
determine the association between single nucleotide polymorphism (SNP) in ApoE (rs7412, rs429358) and CLU (rs11136000,
rs1532278) genes and some biochemical parameters and their association with occurrence of AD. A total of 24 elderly Saudis
subjects (14 males, 10 females) aged between 58-90 years with confirmed diagnosis of AD following the NINCDS-ADRDA and
the DSM-IV criteria and 23 age matched normal subjects (11 males, 12 females) were recruited from King Khalid University
hospital, Riyadh, Saudi Arabia. Serum total cholesterol, LDL-c, HDL-c, and triglyceride levels were measured by Autoanalyzer,
serum concentrations of beta-amyloid 1-40, beta-amyloid 1-42, and clusterin were analysed by ELISA, and gene polymorphism
were analysed by RT-PCR using Taqman assay. For ApoE rs429358 patients showed significantly increased frequency of TC
allele than control [p= 0.017, OR= 7.87, 95% CI (1.45-42.61)]. Whereas for CLU rs11136000 GG frequency was significantly
increased in control than in patient [p=0.052, OR=0.18, 95% CI (0.03 - 1.02)] while in the other SNP for CLU rs1532278 GA
allele was significantly higher in patient than in control [p= 0.056, OR= 3.71, 95% CI (0.97 - 14.2)]. In conclusion, genetic
variants in ApoE and CLU genes may be associated with increased risk of Alzheimer's disease among Saudi subjects.
Biography
Nouf Nasser Abduallah AlGhunaim is Protein Researcher Chair in King Saud University, and worked as an intern of Nanotechnology
Nouf Al Ghunaim et al., J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C8-058