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conferenceseries.com
Volume 7, Issue 6 (Suppl) J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460 Dementia 2017
October 16-18, 2017
ALZHEIMER’S DISEASE & DEMENTIA
October 16-18, 2017 | Rome, Italy
9th International Conference on
The role of animal models in neuropsychiatric research
Tejkalová Hana1, František Jelínek2, Jan Klaschka3 and Jiří Horáček1
1National Institute of Mental Health, Czech Republic
2Veterinary Histopathological Laboratory, Prague
3Institute of Computer Science of the Czech Academy of Sciences, Czech Republic
At present, animal models are viewed as useful and widespread tools in translational neuroscience research and
CNS drug development. To mimic brain pathogenesis and the spectrum of quantifiable disease endpoints in human
neurodevelopmental disorders many model studies are done, using mainly rodents. We can evaluate many patterns in the
ethogram exhibited by the species used in specific experimental situations. It has recently become increasingly important to
develop translational models that enable multiple behavioural domains to be explored in parallel together, combined with
other data obtained from various animal tissues to evaluate useful biochemical and morphology analyses. The results of these
translational models depend on well-defined requirements for animal models that take into account the ethological approach,
the biology of experimental animals used, the life history of individuals and many other factors in order to produce a good
project with valuable data. Alzheimer disease (AD) is characterized by gradual cognitive decline, sensory and motor deficits
and is the primary cause of dementia. To examine the role of early neuroinflammation in neurodevelopmental diseases, a
translational model with neonatal subchronic lipopolysaccharide (LPS) insult was used. Our finding suggests that LPS may
have long-lasting effects on the future development of behavioural parameters together with altered morphological markers.
Animal models of neuropsychiatric and neurology disorders are indispensable tools for studying target key neurobehavioural
domains of these diseases and help to provide better insights into the complexity of brain functions, brain pathogenesis and
find novel biomarkers and therapies.
Biography
H Tejkalova obtained both her degree at the age of 24 and her later PhD. from the Faculty of Science, Charles University in Prague. She is a senior researcher at
the National Institute of Mental Health (NIMH). She has published nearly 50 papers in reputed journals (total citations 177, inc. self-citations). Her research activities
involve the use of behaviour in the animal modelling of psychiatric disorders, especially schizophrenia. She also acted as the Czech representative in FELASA
from 2010 until 2014.
Tejkalová Hana et al., J Alzheimers Dis Parkinsonism 2017, 7:6(Suppl)
DOI: 10.4172/2161-0460-C1-033