2 / 4
Volume 7, Issue 6 (Suppl)
J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460
Dementia 2017
October 16-18, 2017
Page 20
conference
series
.com
ALZHEIMER’S DISEASE & DEMENTIA
October 16-18, 2017 | Rome, Italy
9
th
International Conference on
Zhicheng Xiao, J Alzheimers Dis Parkinsonism 2017, 7:6(Suppl)
DOI: 10.4172/2161-0460-C1-032
APP intracellular domain supperess neuronal differentiation through transcriptional regulation of
mir663
A
myloid precursor protein (APP) is best known for its involvement in the pathogenesis of Alzheimer’s disease. We have
previously demonstrated that APP intracellular domain (AICD) regulates neurogenesis; however, the mechanisms
underlyingAICD-mediated regulation of neuronal differentiation are not yet fully characterized. Using genome-wide chromatin
immunoprecipitation approaches, we found that AICD is specifically recruited to the regulatory regions of several microRNA
genes, and acts as a transcriptional regulator for miR-663, miR-3648 and miR-3687 in human neural stem cells. Functional
assays show that AICD negatively modulates neuronal differentiation through miR-663, a primate-specific microRNA.
Microarray data further demonstrate that miR-663 suppresses the expression of multiple genes implicated in neurogenesis,
including FBXL18 and CDK6. Our results indicate that AICD has a novel role in suppression of neuronal differentiation via
transcriptional regulation of miR-663 in human neural stem cells.
Biography
Zhi-cheng Xiao received a Doctor of Natural Science Degree from Swiss Federal Institute of Technology, Zurich. He is current Professor in Monash University. He is the
CEO & CFO of iNovaFarm, a premier Bio-Tech company. He has published more than 100 papers in reputed journals and serving as editorial board members of more
than 10 journals.
zhicheng.xiao@monash.eduZhicheng Xiao
Monash University, Australia