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Volume 6 Issue 5(Suppl) J Alzheimers Dis Parkinsonism 2016
ISSN:2161-0460 JADP, an open access journal
Page 42
Dementia 2016
September 29-October 01, 2016
conferenceseries.com
September 29-October 01, 2016 London, UK
5th International Conference on
Alzheimer’s Disease & Dementia
Xiaoliang Wang, J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)
Study on Diabetes Induced Dementia and the Mechanisms of Synaptic Plasticity in KK-Ay Mice
Diabetes mellitus (DM) may induce dementia, so-called diabetic encephalopathy. In the present study, the spontaneously
obesity-induced Type 2 diabetic model, KK-Ay mice were used to study the relationship between spatial learning and
memory deficits and the alteration of hippocampal synaptic plasticity.Our results showed that KK-Ay mice presented typical
T2DM syndrome and deterioratedprogressivelyinMorris water maze from early stage (3 month old). Meanwhile, Aßdeposition
and Tau phosphorylation increased in hippocampus. LTP (long term potentiation) was also impaired significantly. It is
interesting that these deficits in KK-Ay mice could be relieved by diet intervention and anti-AD drugs. Further, we found that
the underlying mechanisms of LTP impairment in KK-Ay mice might attribute to abnormal phosphorylation or expression
of glutamate receptors subunits rather than alteration of basal synaptic transmission. The expression levels of NR1, NR2A
and NR2B subunits of NMDA receptors (NMDARs) were unchanged while the Tyr-dependent phosphorylations of NR2A
and NR2B subunits were significantly reduced in KK-Ay mice. The p-Src and CaMKII were also down addition,
AMPA receptor, GluR1 was decreased, and the GluR2 was significantly summary, ourresults suggest that deficits
in learning and plasticity in KK-Ay mice may mainly arise from the abnormalof NR2 subunits, which were related to the
activities of p-Src and CaMKII. It might be recovered by diet interventionand anti-AD treatment.
Biography
Wang,Xiaoliang has completed his MD from University of Essen, Germany in 1987. He returned to the Chinese Academy of Medical Sciences, Beijing in 1988 and
promoted to full professor in 1993. He served as director of Institute of MateriaMedica, CAMS from 1997 to 2010. His research fields including neurodegenerative
diseases, drug discovery and development. He has published 200 papers in reputed journals and has been serving as editorial board membersfor several journals.
Xiaoliang Wang
Chinese Academy of Medical Sciences, China