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conferenceseries.com
Volume 6, Issue 8 (Suppl) J Nutr Food Sci
ISSN:2155-9600 JNFS, an open access journal Clinical Nutrition 2016
December 08-10, 2016
December 08-10, 2016 Dubai, UAE
8th International Conference on
Clinical Nutrition
Vitamin D status, dyslipedemia and markers of endothelial activation in Australian adults
Ali Alyami
Curtin University, Australia
There is increasing interest in the extra-skeletal effects of vitamin D on chronic diseases including CVD. The objective of this study
was to determine whether circulating lipids, systemic inflammation and biomarkers of endothelial cell activation varied across
vitamin D status of older Australians. One hundred and one participants were proportionately sampled across tertile (T1=lowest,
T2=middle, T3=highest) of 25(OH)D3 from a larger cohort of free living older adults. Blood samples after an overnight fast were
assayed for PTH, insulin, TAG, total cholesterol and lipid fractions. Markers of systemic inflammation and endothelial activation
included hsCRP, TNF- α, hepatocyte growth factor (HGF), P-selectin and soluble vascular cell adhesion molecule (sVCAM) amongst
others. Eighty three participants (48 women, 35 men) aged 65±7.7 years; BMI 28±4.5 kg/m2 with complete data entered the analysis.
A general linear model multivariate analysis with a backward elimination stepwise procedure was performed (SPSS version 22). The
final model built based on a parsimonious model, which included age, gender, BMI, McAuley’s index as confounders but excluded
season, medications and PTH, indicated that there were significant differences across vitamin D tertile in TC (T1>T3, p=0.003),
LDL-C (T1>T3, p=0.005), HGF (T1<T3, p=0.009; T2<T3, P=0.047) and sVCAM (T1<T3, P=0.04). Lower vitamin D status was
associated with higher total and LDL cholesterol and lower HGF and sVCAM. Overall the data are suggestive of a role for the vitamin
in CVD.
Biography
Ali Alyami is a Clinical Dietitian, obtained his Bachelor’s degree from King Saud University 2004 and Master’s degree from Canberra University in 2011. He is
currently pursuing his PhD at Curtin University, Perth, Western Australia.
Ali Alyami, J Nutr Food Sci 2016, 6:8 (Suppl)