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Notes:
Volume 7, Issue 6 (Suppl)
J Gastrointest Dig Syst, an open access journal
ISSN: 2161-069X
Page 28
December 07-08, 2017 Madrid, Spain
&
13
th
International Conference on Clinical Gastroenterology & Hepatology
2
nd
International Conference on Digestive Diseases
CO-ORGANIZED EVENT
Role of aromatase
(CYP19A1)
in colorectal cancer etiology, and effect of gene polymorphisms in
cancer development and treatment
Arjumand Warsy, Fatimah Basil al-Mukaynizi, Mohammed Alanazi, Sooad AlDaihan, Parine, Majid Almadi, Abdulrahman Aljebreen, Nahla Azzam,
Othman Alharbi, Maha Arafah
and
Narasimha Reddy
King Saud University, Saudi Arabia
I
n the last decade, the role of estrogens in the etiology of cancer has been well documented. Estrogen levels have been
implicated as both protective and predisposing factors in cancer development. Studies have shown that the production of
estrogens in tissues results in local elevation and has a deteriorating effect on cancer development and prognosis. Aromatase
cytochrome p450 enzyme (
CYP19A1
) is involved in the synthesis of estrogens and converts estrone to estradiol. It has become
a target of extensive research, where aromatase inhibitors are employed as treatment strategies for several cancers. Several
genetic variations have been reported in the
CYP19A1
gene that alters aromatase expression or its activity and influence the
risk of cancer development. We genotyped six single nucleotide polymorphisms (SNPs) (rs4774585, rs936308, rs4775936,
rs28757184, rs700518 and rs4646), in
CYP19A1
gene in patients suffering from colorectal cancer, and compared the results
with normal healthy controls. We also studied the level of gene expression of aromatase in cancer tissue compared to adjacent
normal tissue. The SNP rs936308 was significantly associated with rectal cancer, rs4774585 to colorectal cancer in male patients
and rs4775936 in the female patients. The aromatase gene expression was elevated in the cancer tissue and aromatase protein
level was high as confirmed by immunohistochemistry. In silico studies were conducted on rs28757184, a missense mutation,
and showed structural variations. This presentation will discuss the role of aromatase in colorectal cancer development and will
present the genetic variations reported so far and their effect on the pathogenesis of colorectal cancer.
Biography
Arjumand Warsy is a Professor at Department of Biochemistry in the College of Science at King Saud University, Saudi Arabia. She has completed his PhD in 1974
from the Department of Applied Biochemistry and Nutrition at University of Nottingham, UK. Her title thesis is: Study of proteinase inhibitors in seeds of Vacia faba
(Broad Bean). She was a Post‑doctoral Research Associate at Department of Biochemistry, University of Birmingham, UK from 1973‑1975. She joined Department
of Biochemistry, College of Medicine, Sciences and Medical Studies, Department for Women Students, King Saud University in 1977.
aswarsy@gmail.comArjumand Warsy et al., J Gastrointest Dig Syst 2017, 7:6(Suppl)
DOI: 10.4172/2161-069X-C1-058