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Volume 7, Issue 3 (Suppl)
J Obes Weight Loss Ther, an open access journal
ISSN: 2165-7904
Childhood Obesity & Bariatric Surgery 2017
June 12-13, 2017
Page 45
Notes:
conference
series
.com
June 12-13, 2017 Rome, Italy
&
Childhood Obesity and Nutrition
10
th
International Conference on
Metabolic and Bariatric Surgery
2
nd
International Conference on
JOINT EVENT
Obesity and GLP-1: Obesity pathophysiology and GLP-1 treatment potential
O
besity impairs almost all aspects of health and is a global challenge to our healthcare system as the prevalence reaches to 1
billion humans. Therefore, there is an acute need for better prevention and treatment strategies. Glucagon-like-peptide-1
(GLP-1), secreted from endocrine cells in the intestine upon meal intake, reduces food intake. We have previously shown that:
Obese people have low endogenous GLP-1 response; weight loss induces a marked increase in GLP-1 response and; treatment
with GLP-1 analogues facilitates long term weight loss maintenance (12 kg) accompanied by substantial improvement in
metabolic health, compared to diet-induced weight loss maintenance. Chronic inflammation is an established part of the
pathogenesis of obesity and activation of macrophages and T-cells in the expanded adipose tissue is coupled to the development
of a pro-inflammatory state and insulin resistance. Interestingly, emerging evidence identifies GLP-1 as a potentially important
immuno-modulator. GLP-1 decreases inflammation-associated gene and protein expression in macrophages and exerts anti-
inflammatory actions in adipocytes and endothelial cells as well as potent anti-inflammatory effects in humans.
Biography
Signe Torekov is currently an Associate Professor at University of Copenhagen, Denmark. She has a strong background in metabolic translational research. She has
authored 30 original peer-reviewed papers; much of this work has been published in high-ranking journals in the field. In 2016, she has received the prestigious Novo
Nordisk Foundation Excellence Fellowship. In 2015, she formed an international alliance in immuno-metabolism with top researchers at Oxford and Karolinska University.
torekov@sund.ku.dkSigne Torekov
University of Copenhagen, Denmark
Signe Torekov, J Obes Weight Loss Ther 2017, 7:3 (Suppl)
DOI: 10.4172/2165-7904-C1-044