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conferenceseries
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Volume 6
Journal of Cardiovascular Diseases & Diagnosis
Cardiology Care 2018
August 09-11, 2018
August 09-11, 2018 Abu Dhabi, UAE
Cardiology and Healthcare
28
th
International Conference on
Modified ultrafiltration versus conventional ultrafiltration in adults undergoing coronary artery
bypass grafting-effects on inflammatory cytokine response, rotational thromboelastometry
parameters and hemodilution: A randomized controlled trial
Farhad Gorjipour
1,2
1
Shaheed Rajaei Cardiovascular Medical and Research Center, Iran
2
Iran University of Medical Sciences, Iran
Statement of the Problem:
Cardiopulmonary bypass is associated with increased inflammatory system responses and alterations
of the hemostatic factors and coagulation system. Modulation of the inflammatory response through medical and non-medical
approaches is important in reducing the post-operative complications. In the present study we investigated the outcomes of using
Modified Ultra Filtration (MUF) in adults undergoing Coronary Artery Bypass Grafting (CABG) operation.
Method:
56 patients candidate for elective CABG were randomly assigned in two groups including Conventional Ultra Filtration
(CUF) and MUF groups. Preoperative and postoperative clinical parameters, serum level of inflammatory cytokines and ROTEM
indices were measured pre-operation, after de-clamping of aorta, Intensive Care Unit (ICU) entrance and on 24 and 48 hours
after operation.
Findings:
Two groups were similar in the clinical perioperative parameters including hemodynamics, transfusions, ROTEM
indices, mechanical ventilation and cardiopulmonary bypass (CPB) time and ICU stay. Interleukin (IL)-6, -8 and -10 measures
were equal between two groups in all trial measurement points. The levels of inflammatory mediators were significantly increased
after CPB in both groups. TNF-α was significantly elevated after CPB compared with de-clamping time (P<0.05). MUF group
demonstrated significantly lower level of TNF-α compared with CUF group at the same time (P=0.031). Hemoglobin and
hematocrit levels were significantly increased in the MUF group after CPB (P<0.05).
Conclusion:
MUF is effective in improving the hemodynamics and hemoglobin level after CPB among patients undergoing
CABG. It also modulates the immune response post-operation.
gorjipoorf@yahoo.comJ Cardiovasc Dis Diagn 2018, Volume 6
DOI: 10.4172/2329-9517-C1-003