cancer-therapy-and-biomarkers-2016_tracks-abstracts

16 / 36

Volume 2, Issue 3(Suppl) Oncol Cancer Case Rep
ISSN: 2471-8556 an open access journal
Page 43
Notes:
Cancer Therapy & Biomarkers 2016
December 05-07, 2016
conferenceseries.com
CANCER THERAPY,
BIOMARKERS & CLINICAL RESEARCH
15th World Congress on
December 05-07, 2016 Philadelphia, USA
Preoperative neutrophil to lymphocyte ratio predicts central compartment lymph nodes metasta-
sis in papillary thyroid microcarcinoma
Xiequn Xu and Sai Chou
1 Peking Union Medical College Hospital, China
Background: The incidence of Papillary Thyroid Microcarcinoma (PTMC) is rising in most countries, which is a consequence
of efficacy earlier diagnosis. Even though the central lymph nodes metastasis has be considered to be a risk factor of poor prog-
nosis in PTMC, there is no reliable preoperative assessment for it. Our study was to confirm the value of preoperative Neutro-
phil To Lymphocyte Ratio (NLR) to predict the central lymph nodes metastasis of PTMC by retrospective case control study.
Methods: A total of 142 patients who underwent total thyroidectomy with prophylactic central lymph nodes dissection at a
single institution between Oct 2013 and Jan 2015 were analyzed. Patients were categorized into central lymph node metastasis
positive and negative, those were confirmed by histological. Age, gender, blood cells counts with differential counts, medical
history were measured or recorded in each patient before operation.
Results: In our study, 37.14% (n=52) were CLN metastasis positive while 62.86% (n=88) were negative. The factors that cor-
related (P<0.05) with the presence of central lymph node metastases were age and NLR. The NLR were significantly higher
in the Central lymph node negative group (p=0.027). The optimum NLR cut-off value obtained from ROC analysis was 2.32
(Sensitivity 44% and Specificity 87.1%). The optimum Age cut-off value obtained from ROC analysis was 45(Sensitivity 53.1%
and Specificity 76.3%).
Conclusions: Higher preoperative NLR could be a reliable negative marker for central compartment lymph node metastasis
and cut-off value of 2.32 be supposed.
Biography
Xiequn Xu has completed his MD at the age of 27 years from Peking Union Medical College Hospital. He is the associate professer of general surgery in Peking
Union Medical College Hospital, a ranked No 1 hospital in China. He has published more than 30 papers in reputed journals.
Xiequn Xu et al., Oncol Cancer Case Rep 2016,2:3(Suppl)