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Volume 9, Issue 5 (Suppl)
J Cancer Sci Ther, an open access journal
ISSN: 1948-5956
Cancer Stem Cells and Oncology Research 2017
June 26-28, 2017
Page 33
10
th
International Conference on
June 26-28, 2017 London, UK
CANCER STEM CELLS AND
ONCOLOGY RESEARCH
Hypericum triquetrifolium Turra against cyclophosphamide-induced hemorrhagic cystitis in rats
Songul CETIK
1
, Cumali Keskin
1
, Cemil Demir
1
and
Adnan Ayhanci
2
1
Mardin Artuklu University, Turkey
2
Eskisehir Osmangazi University, Turkey
A
cyclophosphamide (CYP) usage is limited by side effects of it, are commonly used as antineoplastic drug. Hemorrhagic cystitis is
one of the most important side effects of CYP chemotherapy. Antioxidants such as
Hypericum triquetrifolium
Turra (HT) show
an important antioxidant and anti-carcinogenic properties with its rich contents. This study investigated the possible cytoprotection
effect of HT (25, 50, 100 mg/kg, i.p., for 6 days) in CYP (150 mg/kg, single dose, i.p.) treated rats, and attempted to obtain a suitable
new agents. Creatinin (CK), malondialdehyde (MDA), total oxidant capacity (TOC), total antioxidant capacity (TAC) and oxidative
stress index (OSI) levels were measured in blood serum. Furthermore, the bladder tissue samples were investigated histopathological.
In the only CYP group CK, MDA, TOC and OSI levels found increased while TAC level decreased. According our results high
dose CYP caused the edema, necrosis, bleeding and tissue erosions, hemorrhage and separation of the muscle fibers supported the
our biochemical results. After pretreatment with HT doses observed an important decrease in the CYP toxicity, decreased the cell
damage and oxidative stress parameters while increased TAC. Based on the present experimental study’s findings, we may say that HT
pretreatment has the potential to be a therapeutic option for the management of CYP-induced HC.
Biography
Songul CETIK is an Assistant Professor at Vocational Higher of Health Services, Mardin Artuklu University in Turkey. She has completed her graduation from
Eskisehir Osmangazi University, Faculty of Arts and Sciences, Department of Biology, 2009. She has done her Post-graduation from Eskisehir Osmangazi
University, Faculty of Science, 2014.
socem47@hotmail.comSongul CETIK et al., J Cancer Sci Ther 2017, 9:5(Suppl)
DOI: 10.4172/1948-5956-C1-102