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Journal of Gastrointestinal & Digestive System | ISSN: 2161-069X | Volume: 8
&
&
October 29-30, 2018 | San Francisco, USA
International Conference on
Gastrointestinal Cancer and Therapeutics
4
th
World Congress on
Digestive & Metabolic Diseases
26
th
Annual Congress on
Cancer Science and Targeted Therapies
Bioactive peptide aglycin for the prevention and treatment of diabetes and non-alcoholic fatty liver
Zhengwang Chen
1
, Xuejun Zhang, Mingzhan Tian
and
Ning Chen
2
1
Zhong-Shi-Du-Qing Biotechnology Co. Ltd., Shandong Tianjiu Industrial Group, China
2
Wuhan Sports University, China
A
glycin, a natural peptide extracted from legume seeds such as pea and soybean, is composed of 37 amino acids with
highly conserved amino acid residues. It has strong resistance to the hydrolysis of digestive proteases to reveal the
excellent stability. Aglycin has an obvious function of stimulating intestinal insulin signaling like GLP-1, thereby promoting
the synthesis and secretion of insulin, and reducing blood glucose level in an animal model with hyperglycemia. Meanwhile, it
also has anti-inflammatory functions in islets to protect the aging and damage of islet beta cells. The underlying mechanisms
are highly correlated with the biosynthesis of glucose transporter-4 and the activation of the insulin receptor, as well as the
enhanced insulin sensitivity. Moreover, this polypeptide also can promote β-oxidation of fatty acids in hepatocytes and inhibit
the production of hepatocytes. Taken together, aglycin can be used as a potential oral polypeptide drug or supplements to
prevent and treat diabetes and non-alcoholic fatty liver disease.
Biography
Zhengwang Chen has completed his PhD Karolinska Institute in Sweden. He is a Professor in School of Life Science and Technology at Huazhong University of
Science and Technology. He is also a senior research scientist of Zhong-Shi-Du-Qing Biotechnology Co. Ltd., Shandong Tianjiu Industrial Group in China. He has
separated, purified and identified serval natural polypeptides with a series of bioactive functions for the prevention and treatment of chronic diseases, which have
been patented for the potential candidates of natural medicines and supplements.
nchen510@163.comZhengwang Chen et al., J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C8-085