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Journal of Clinical & Experimental Pathology | ISSN: 2161-0681 | Volume 8
Breast Pathology and Cancer Diagnosis
6
th
World Congress and Expo on
July 25-26, 2018 | Vancouver, Canada
Medicinal Chemistry and Rational Drugs
20
th
International Conference on
&
Marine bioactive natural products from coral-derived fungi collected from the South China Sea
Chang-Yun Wang
1,2
and
Chang-Lun Shao
1,2
1
Ocean University of China, China
2
Qingdao National Laboratory for Marine Science and Technology, China
S
ymbiotic microorganisms in corals have proven to be a rich source of structurally novel and biologically active secondary
metabolites that have become interesting and significant resources for drug discovery. In recent years, during our ongoing
study on bioactive natural products from the South China Sea, diverse bioactive secondary metabolites with variety structures
have been isolated from coral-derived fungi, such as alkaloids, macrolides, anthraquinones, and peptides. For instance, a
pair of new enantiomeric alkaloid dimers, (+)- and (−)-Pestaloxazine A, with unprecedented symmetric spiro-[oxazinane-
piperazinedione] skeleton, consisting of 22 carbons and 12 heteroatoms, were isolated from a
Pestalotiopsis
sp. fungus derived
from the soft coral
Sarcophyton
sp.. A series of prenylated indole alkaloids were isolated fromAspergillus sp. fungus derived from
the gorgonian coral
Dichotella gemmacea
. Quinazoline alkaloids with heptacyclic skeleton formed via a bridging hemiaminal
linkage was isolated from
Scopulariopsis
sp. fungus derived fromgorgonian
Carijoa
sp. Prenylated dihydroquinolone derivatives
were obtained from the fungus
Aspergillus
sp. cultured from gorgonian
Muricella abnormalis
. And a series of 14-membered
resorcylic acid lactones (RALs) belonging to a family of benzannulated macrolides were obtained from a gorgonian-derived
fungal strain
Cochliobolus lunatus
. The compounds exhibited diverse promising bioactivities, including antifouling activity
against barnacle
B amphitrite,
antibacterial activity towards pathogenic bacteria, cytotoxicity against human tumour cell lines,
and antiviral activity against human respiratory syncytial virus (RSV) and enterovirus 71 (EV 71). It could be concluded
that the bioactive secondary metabolites produced by coral-derived symbiotic microorganisms should be a rich source for
discovery of marine lead compounds.
Biography
Chang-Yun Wang received his PhD degree in marine drugs from Ocean University of China, Qingdao in 1999. From 2000 to 2002, he moved to University of
Duesseldorf, Germany, and joined the research group of Prof. Peter Proksch as a DAAD fellow. Since 1995, he is a professor of marine pharmaceutical chemistry
at Ocean University of China. He is a member of the Commission of Marine Drugs Special Committee, Pharmaceutical Association of China. He has published
more than 100 papers in reputed journals and has been serving as an editorial board member of repute.
changyun@ouc.edu.cnChang-Yun Wang et al., J Clin Exp Pathol 2018, Volume 8
DOI: 10.4172/2161-0681-C3-051