breast-cancer-summit-2017-posters-accepted-abstracts

5 / 20

Page 41
Notes:
conferenceseries.com
Volume 2, Issue 2 (Suppl) Breast Can Curr Res
ISSN: 2572-4118 BCCR, an open access journal Breast Cancer Summit 2017
May 08-10, 2017
May 08-10, 2017 Singapore
4th World Congress on
Breast Cancer
Clinicopathological and prognostic value of programmed death ligand-1 (PD-L1) in breast cancer: A
meta-analysis
Guochao Zhang1, Xue Qi1, Likun Huang2
1Chinese Academy of Medical Sciences and Peking Union Medical College, China
2Shanxi Provincial People’s hospital, China
Background: Programmed death ligand-1 (PD-L1) is an immunological checkpoint protein that has recently been found to be
associated with the prognosis of various malignancies. However, the association between PD-L1 expression and the survival of breast
cancer patients has remained unclear. Therefore, the aim of the present meta-analysis was to assess the clinical value of PD-L1 in
breast cancer patients.
Methods: MEDLINE/PubMed, EMBASE, Cochrane Library, and Grey Literature databases were searched up to 30 March 2016 for
articles involving an association between PD-L1 expression and breast cancer prognosis. Hazard ratios for overall survival with 95%
confidence intervals (CIs) according to the expression status of PD-L1 were calculated. Odds ratios (ORs) were also analyzed to
evaluate the association between clinicopathological parameters and PD-L1 expression.
Results: Ten studies were included in this meta-analysis and 7 of these described clinicopathological features. Elevated levels of PD-
L1 were only significantly associated with histological grade (OR = 1.86, 95% CI: 1.38–2.51; Pheterogeneity = 0.0196), estrogen receptor
status (ER) (OR = 0.36, 95% CI: 0.17–0.75; Pheterogeneity = 0.000), and progesterone receptor status (PR) (OR = 0.31, 95% CI: 0.11–0.86;
Pheterogeneity = 0.000).
Conclusion: There were trends observed in the present meta-analysis, although PD-L1 status as a predictor of prognosis for patients
with breast cancer could not be confirmed. Therefore, further studies of mechanism(s) related to PD-L1 expression level and immune
escape and antitumor immune responses are needed, especially in relation to breast cancer subtypes. Furthermore, an evaluation
standard for PD-L1 expression would facilitate all future studies.
Biography
Zhang Guochao is working as a resident for the second year in Peking Union Medical College and Hospital at present.
Guochao Zhang et al., Breast Can Curr Res 2017, 2:2(Suppl)