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conferenceseries

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Volume 2, Issue 2 (Suppl)

Breast Can Curr Res

ISSN: 2572-4118 BCCR, an open access journal

Breast Cancer Summit 2017

May 08-10, 2017

May 08-10, 2017 Singapore

World Congress on

Breast Cancer

Vitamin D and biphosphonate in neoadjuvant advanced breast cancer

Selma Sakhri

Medical oncology, Algeria

Purpose:

Vitamin D and calcium deficiency is associated with increased breast cancer risk and decreased breast cancer survival. The

purpose of this study is to determine whether the addition of vitamin D and Zoledronic Acid (ZA) to Neoadjuvant Chemotherapy

(NACT) gives complete histological responses. We report a prospective evaluation comparing complete pathological response between

different biomolecular sub-groups.

Patients&Methods:

The study included431womenwith stages III locally advancedbreast cancerwho receivedneoadjuvant chemotherapy

and Zoledronic acid. All patients were prescribed vitamin D3 (cholecalciferol) 400 IU and calcium carbonate 1,000 mg daily. The main

objective is the complete histologic response. Secondary endpoints were the overall survival of patients targeted by the study.

Results:

Histologic complete response with Zoledronic acid and vit Dwas 40.13% .the higher in the subgroupHer2/luminal (RH±Her2+)

and under Her2+ (HR-Her2+) and the lowest rate was observed in the triple negative group as classified by Sataloff, overall survival was

45.77 months for subgroups (Her2/luminal and in Her2+ group) vs. 44.11 months for triple negative group.

Conclusion:

Our study confirms the potential protective effects in vitamin D in neoadjuvant breast cancer.

Selma Sakhri, Breast Can Curr Res 2017, 2:2(Suppl)