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Volume 9
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Biotechnology 2019
Enzymology 2019
February 28-March 02, 2019
&
Page 42
Notes:
conference
series
.com
JOINT EVENT
February 28-March 02, 2019 | Berlin, Germany
5
th
International Conference on
Enzymology and Protein Chemistry
&
22
nd
Global Congress on
Biotechnology
Oara Neumann, J Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C2-114
Plasmonic nanostructures for imaging and targeting drug delivery
E
ngineering a compact, near-infrared plasmonic nanostructure with integrated image enhancing agents for combined imaging
and therapy is an important nano-medical challenge. To overcome this challenge we designed a nanostructure with NIR
plasmonic signatures composed of a 50 nm Au core surrounded a SiO
2
inner-shell doped with contrast agents and an outer Au
shell. The plasmon resonance of this nanostructure known as a nano-Matryoshka (NM), can be tuned to the desired wavelength
by varying the thickness of the layers. The encapsulated contrast agents used in this study are Fe(III)-DOTA, Gd(III)-DOTA
and fluorescent dyes. The Fe(III)-NM based contrast agents are found to have relaxivities two times greater than the widely used
Gd(III)-DOTA, providing a practical alternative for T1 MRI contrast agent that eliminates Gd(III) patient exposure entirely.
Additionally, the internalization of fluorescent dyes and MRI contrast imaging agents within the NM substantially reduces the
toxicity while maintaining a free nanoparticles surface for further bio-functionalization.
Biography
Oara Neumann is the Peter M and Ruth L Nicholas Research Scientist at Rice University (a fully funded, endowed research scientist position at the university). She has
completed her PhD and Postdoctoral study in Applied Physics at Rice University, MSc in Chemical Physics at Weizmann Institute of Science, Israel and another MSc
in Analytical Chemistry from Bucharest University, Romania. She is the Pioneer of nanoparticle-based solar thermal applications. She holds several patents and has
published more than 25 refereed articles and has an h-index of 16.
Oara.Neumann@rice.eduOara Neumann
Rice University, USA