biopolymers-and-bioplastics-2016_posters-accepted-abstracts

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Biopolymers and Bioplastics 2016
September 12-14, 2016
Volume 7, Issue 5(Suppl) J Bioremed Biodeg 2016
ISSN: 2155-6199 JBRBD, an open access journal
conferenceseries .com
September 12-14, 2016 San Antonio, USA
3rd International Conference and Exhibition onBiopolymers & Bioplastics
J Bioremed Biodeg 2016, 7:5(Suppl)
Biodegradable poly(propylene carbonate)-based composite: An alternative biomaterial to polylactic acid
Fariba Dehghani1, Iman Manavitehrani1, Ali Fathi1, Yiwei Wang1 and Peter K Maitz1,2
1University of Sydney, Australia
2Concord Repatriation General Hospital, Australia
Poly(lactic acid) (PLA) and other polyester-based polymers are broadly used in biomedical applications due to their
favourable mechanical strength and biodegradable properties. However, the acidic properties of their degradation
products may lead to clinical complications, such as inflamation, long-term osteoporosis and other unpredictable issues. In
this study, we demonstrate the superior properties of the poly(propylene carbonate) (PPC)-starch composite as an alternative
to polyester-based biomaterials. The degradation products of PPC-starch are mainly carbon dioxide and water. Hence, the pH
in the surrounding tissues of an implant fabricted from this composite does not decrease. Moreover, the mechanical strength
of PPC-starch composites is tuneable within the range of 0.2±0.03 MPa to 33.9±1.51 MPa, by varying the starch content
from 0-50 w%. PPC-starch composites are cytocompatible as osteoblast cells adhere and proliferate on their surface within
seven days. The long-term biocompatibility of PPC-starch is assessed via subcutaneous implantation in mice. The results of
histological analysis demonstrate no symptom of inflammation for PPC-starch composite after eight weeks implantation, while
the biodegradation of PLA lead to massive immune cell infusion and inflammation. These results underline that PPC-starch is
suitable for biomedical applications and can be used for the musculoskeletal tissue regeneration.
Figure 1: The explanation site of PPC-ST50 (a) and PLA (b) 8 weeks post-surgery, and haematoxylin and eosin staining of
paraffin sections of the implantation site at 8 weeks around PPC-ST50 composite (c) and PLA (d). After 8 weeks a prominent
foreign body reaction is observed around PLA implantation zone. However, the inflammatory response to the PPC-ST50
composite is resolved dramatically.
Preparation of some chitosan derivatives and study of their effect on human genetic material
Hadi S Al-Lami, Sara H Mutasher and Afrodet A Salih
University of Basrah, Iraq
C hitosan is a polycation biopolymer material. It has several applications, especially in the biopharmaceutical and biomedical
fields. Chitosan was produced from shrimp waste by chemical method involving demineralization, deproteinization and
deacetylation. It was characterized by intrinsic viscosity measurement and Fourier transform infra-red in order to determine
the average molecular weight and degree of deacetylation of purified chitosan. Chitosan was modified by grafting process
with maleic anhydride, poly(adipic anhydride) and poly(sebacic anhydride) to evaluate their effect on binding to the human
genomic DNA. The grafted chitosan derivatives appeared as promising materials to be used as a model for DNA and gene
delivery. Grafted chitosan-DNA complexes were determined by gel electrophoresis technique and ultraviolet spectroscopy.