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Volume 8 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Bariatric Surgery 2018 & Gastro 2018
March 15-16, 2018
JOINT EVENT
12th Global Gastroenterologists Meeting
3rd International Conference on Metabolic and Bariatric Surgery
&
March 15-16, 2018 Barcelona, Spain
Epidemiological and clinical evaluation of hepatitis b, hepatitis c, and delta viruses in Tajikistan
Khakimova Zebinniso
Institute of Gastroenterology - Academy of Medical Sciences of the Ministry of Health and Social Protection, Tajikistan
The implication of genotypes is recognized increasingly in the clinical course of hepatitis B virus (HBV) and in response
to anti-viral drugs of hepatitis C virus (HCV). Genotypic prevalence of both etiological agents variesgeographicallyand
no data are available for Tajikistan. To investigate the epidemiology and clinical significance of HBV and HCVgenotypes in
chronic hepatitis (group 1) and liver cirrhosis/hepatocellular carcinoma (HCC) (group2) patients in Tajikistan, 124 patients
with chronic liver disease (group 1=84 and group 2=40) were enrolled. Genotypes of HBV, HCV, and delta hepatitis virus
(HDV) were deter¬mined by sequencing. The overall prevalence of anti-HCV, HCV coreantigen (HCVcAg)and HBsAg was
46% (57/124) and 41.1% (51/124), respec¬tively. Coinfection of HCV/HBV, HBV/HDV, and HCV/HBV/HDV was found in
4.8% (6/124), 11.2% (12/124), and 0.8% (1/124) of cases, respectively. HDV genotype 1 was found in 19.6% (10/51) of HBsAg-
positive patients. The HBV/HDV coinfec- tion was relatively high in group 2 compared to group 1 (15%vs.7.1%). HCV/1b
detected in 84.6% (44/52) of HCVRNA-positive patients,followed by 3a (7.6%), 2a (5.7%), and 2c (1.9%). HBV/D was detected
in 94.1% (48/51) of HBsAg-positive patients, followed by HBV/A [5.8% (3/51)]. T1762/A1764 double mutation was associated
with livercirrhosis/HCC in HBV-infected patients (P=0.0004). This is the first study on the molecular epidemiology of hepatitis
viruses among chronic liver diseases patients in Tajikistan. Among HBV-infected patients, the T1762/A1764 mutation was
associated with liver cirrhosis/HCC.
Biography
Khakimova Zebinniso is affiliated to the Department of Virology, Institute of Gastroenterology of the Republic of Tajikistan. She has published more than 5 papers
in reputed journals.
Khakimova Zebinniso, J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C1-065